Method of making wound gel containing antimicrobial composition
A gel useful in reducing bacterial colonization in or around the area of a wound can be provided from at least one PEG and an aqueous composition having a pH of from 2 to 4, a total solute concentration of from 1.8 to 4.0 Osm/L, and from 0.9 to 1.7 g/L of at least one cationic surfactant. The aqueous composition can include a buffer system that includes an organic acid and a salt of an organic acid. The resulting gel is effective even when free of materials having antimicrobial properties other than those provided by the aqueous composition such as sporicides, antifungals and antibiotics.
1. A method of making a gel useful in reducing bacterial colonization in or around the area of a wound, said method comprising combining at least one PEG and an aqueous composition having a pH of from 2 to 4, a total solute concentration of from 1.8 to 4.0 Osm/L, and from 0.9 to 1.7 g/L of at least one cationic surfactant so as to provide said gel, said gel being free of sporicides, antifungals and antibiotics.
2. The method of claim 1 wherein said composition has a total solute concentration of from 1.8 to 2.8 Osm/L.
3. The method of claim 1 wherein said at least one cationic surfactant comprises benzalkonium chloride.
4. The method of claim 1 wherein said at least one cationic surfactant is benzalkonium chloride.
5. A process for making a gel useful in reducing bacterial colonization in or around the area of a wound, said process comprising blending ingredients that consist essentially of (a) at least one PEG, (b) an aqueous composition having a pH of from 2 to 4, a total solute concentration of from 1.8 to 4.0 Osm/L, and from 0.9 to 1.7 g/L of at least one cationic surfactant, and (c) optionally one or more of an emollient, a lotion, a humectant, a glycosaminoglycan, an analgesic, colloidal silver and a coalescent, thereby providing said gel.
6. The process of claim 5 wherein said at least one cationic surfactant is benzalkonium chloride.
7. The process of claim 5 wherein said composition comprises a buffer system that comprises of one or more organic acids and at least one salt of one or more organic acids.
8. The process of claim 5 wherein said at least one cationic surfactant is benzalkonium chloride.
9. A method for providing a gel useful in reducing bacterial colonization in or around the area of a wound, said method comprising blending
a) at least one PEG and
b) a composition having a pH of from 2 to 4 and a total solute concentration of from 1.8 to 4.0 Osm/L that consists essentially of
(1) water,
(2) a buffer system that comprises of one or more organic acids and at least one salt of one or more organic acids, and
(3) from 0.9 to 1.7 g/L of at least one cationic surfactant, thereby providing said gel, said gel being free of materials having antimicrobial properties other than those provided by said composition.
10. The method of claim 9 wherein said composition has a total solute concentration of from 1.8 to 2.8 Osm/L.
11. The method of claim 9 wherein said at least one cationic surfactant comprises benzalkonium chloride.
12. The method of claim 9 wherein said at least one cationic surfactant is benzalkonium chloride.
13. The method of claim 9 wherein said one or more organic acids comprise at least one polyacid.
14. The method of claim 13 wherein said at least one polyacid comprises citric acid.
15. The method of claim 14 wherein said at least one salt of one or more organic acids comprises a salt of a polyacid.
16. The method of claim 9 wherein each of said one or more organic acids is a polyacid.
17. The method of claim 9 wherein said one or more organic acids is citric acid.
18. The method of claim 17 wherein said at least one salt comprises a salt of citric acid.
19. The method of claim 9 wherein said at least one salt is a salt of citric acid.
20. The method of claim 9 wherein said one or more organic acids is acetic acid.