Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide
Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used reduce the amount of times the sensor goes offline. Systems and methods described may factor in actions occurring at the delivery system and/or aspects of the surrounding environment, prior to performing a baseline calibration, and may postpone the calibration and/or rejected using the sensor's output for the calibration.
1. A method for compensating for sensor drift in a nitric oxide delivery system, the method comprising:
storing, in memory associated with the nitric oxide delivery system, a baseline calibration value and a calibration schedule;
initiating a boot-up sequence of the nitric oxide delivery system;
performing a baseline calibration after initiating the boot-up sequence;
receiving a checkout instruction from a user, wherein the checkout instruction is input by the user during the boot-up sequence;
running the checkout, wherein the checkout is run during, and in parallel with, the baseline calibration, wherein the checkout requires access to a gas monitor associated with the nitric oxide delivery system;
verifying, during an attempt to access the gas monitor during the checkout, that the baseline calibration has completed; and
delivering, via the nitric oxide delivery system, a predetermined dosage of nitric oxide to a patient,
wherein the calibration schedule is modified based upon a change in the predetermined dosage of nitric oxide being delivered to the patient, and
wherein a calibration, according to the calibration schedule, occurs with greater frequency as the change in the predetermined dosage is larger.
2. The method of claim 1 wherein if the baseline calibration has not completed, the method further comprises notifying the user that delivery of nitric oxide to the patient must be postponed until the baseline calibration has completed.
3. The method of claim 2 wherein the user is further prevented from proceeding to a next step via notifying the user by displaying a notification that the measuring of the nitric oxide gas concentration is off-line and includes displaying notification for an additional period of time after performing the calibration.
4. The method of claim 3 wherein the next step comprises performing delivery and performance monitoring tests.
5. The method of claim 4 wherein the delivery and performance monitoring tests are performed with the gas monitor.
6. The method of claim 1 wherein if it is verified that the baseline calibration has completed, the system is operable to allow the user to proceed to a next step.
7. The method of claim 1 further comprising:
determining that the sensor is calibrated; and
determining that the baseline value stored in memory is accurate.
8. The method of claim 1 wherein the baseline calibration begins before a user enters an initial set dose.
9. The method of claim 1 wherein the baseline calibration completes before a user enters an initial set dose.
10. The method of claim 1 wherein the baseline calibration is performed to reset the baseline calibration value.
11. The method of claim 1 wherein the baseline calibration is performed to compensate for sensor desaturation.
12. The method of claim 1 wherein the baseline calibration is performed upon powering on the nitric oxide delivery system.
13. The method of claim 1 wherein the baseline calibration is performed prior to initiating a therapy session.
14. The method of claim 1 further comprising performing a default calibration upon boot-up, wherein the default calibration is performed every 24 hours.
15. A method for compensating for sensor drift in a nitric oxide delivery system, the method comprising:
storing, in memory associated with the nitric oxide delivery system, a baseline calibration value and a calibration schedule;
initiating a boot-up sequence of the nitric oxide delivery system;
performing a baseline calibration after initiating the boot-up sequence;
receiving a checkout instruction from a user, wherein the checkout instruction is input by the user during the boot-up sequence;
running the checkout, wherein the pre-use checkout is run during, and in parallel with, the baseline calibration, and wherein the checkout requires access to a gas monitor associated with the nitric oxide delivery system;
verifying, during an attempt to access the gas monitor during the pre-use checkout, that baseline calibration has not completed;
notifying the user that delivery of nitric oxide to the patient must be postponed until baseline calibration has been completed; and
delivering, via the nitric oxide delivery system, a predetermined dosage of nitric oxide to a patient,
wherein the calibration schedule is modified based upon a change in the predetermined dosage of nitric oxide being delivered to the patient, and
wherein a calibration, according to the calibration schedule, occurs with greater frequency as the change in the predetermined dosage is larger.
16. The method of claim 15 wherein the user is prevented from performing delivery and monitoring performance tests until baseline calibration has completed via notifying the user by displaying a notification that the measuring of the nitric oxide gas concentration is off-line and includes displaying notification for an additional period of time after performing the calibration.
17. The method of claim 15 further comprising:
determining that the sensor is calibrated; and
determining that the baseline value stored in memory is accurate.
18. The method of claim 15 wherein the baseline calibration begins before a user enters an initial set dose.
19. A method for compensating for sensor drift in a nitric oxide delivery system, the method comprising:
storing, in memory associated with the nitric oxide delivery system, a baseline calibration value and a calibration schedule;
initiating a boot-up sequence of the nitric oxide delivery system;
performing a baseline calibration after initiating the boot-up sequence;
receiving a checkout instruction from a user, wherein the checkout instruction is input by the user during the boot-up sequence;
verifying, during an attempt to access the gas monitor during the checkout, that baseline calibration has not completed;
notifying the user that delivery of nitric oxide to the patient must be postponed until baseline calibration has been completed, wherein the notifying includes displaying a notification that the measuring of the nitric oxide gas concentration is off-line and includes displaying notification for an additional period of time after the performing of the calibration is completed;
preventing the checkout from running until the baseline calibration has completed; and
delivering, via the nitric oxide delivery system, a predetermined dosage of nitric oxide to a patient,
wherein the calibration schedule is modified based upon a change in the predetermined dosage of nitric oxide being delivered to the patient, and
wherein a calibration, according to the calibration schedule, occurs with greater frequency as the change in the predetermined dosage is larger.
20. The method of claim 19 wherein the baseline calibration is performed upon powering on the nitric oxide delivery system.