Oral drug delivery system
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
1. A method of providing pain relief to a subject in need thereof, comprising orally administering to the subject an effective amount of a composition comprising:
an opioid selected from buprenorphine, butorphanol, hydrocodone, hydromorphone, levorphanol, meperidine, methadone, morphine, oxycodone, oxymorphone, and tramadol, or a pharmacologically effective salt thereof;
sucrose acetate isobutyrate (SAIB);
a cellulose acetate butyrate (CAB) having a number average molecular weight ranging from 66,000 Daltons to 83,000 Daltons; and
a solvent.
2. The method of claim 1 , wherein the opioid is present in an amount ranging from about 2 mg to about 250 mg.
3. The method of claim 1 , wherein the opioid comprises hydrocodone, hydromorphone, levorphanol, morphine, oxymorphone, or oxycodone.
4. The method of claim 1 , wherein the composition comprises from about 20 weight percent to about 90 weight percent of the SAIB.
5. The method of claim 1 , wherein the CAB has a butyryl content ranging from about 17% to about 38%.
6. The method of claim 1 , wherein the CAB has an acetyl content ranging from about 13% to about 30%.
7. The method of claim 1 , wherein the CAB has a butyryl content ranging from about 17% to about 38% and an acetyl content ranging from about 13% to about 30%.
8. The method of claim 1 , wherein the CAB has at least one feature selected from a butyryl content ranging from about 17% to about 38%, an acetyl content ranging from about 13% to about 30%, and a hydroxyl content ranging from about 0.8% to about 1.7%.
9. The method of claim 1 , wherein the composition comprises from about 20 weight percent to about 50 weight percent of the solvent.
10. The method of claim 1 , wherein the solvent comprises propylene carbonate, N-methylpyrrolidone (NMP), glycofurol, alpha-tocopherol, diethyl phthalate, or polyethylene glycol 400 (PEG 400).
11. The method of claim 1 , wherein the solvent comprises triacetin or ethyl lactate.
12. The method of claim 1 , wherein the composition further comprises a member selected from caprylic/capric triglyceride, isopropyl myristate (IPM), ethyl oleate, dimethyl phthalate, and benzyl benzoate.
13. The method of claim 1 , wherein the composition is contained in a capsule.
14. The method of claim 13 , wherein the capsule comprises gelatin or hydroxyl propylmethyl cellulose.
15. The method of claim 13 , wherein the capsule comprises a hard capsule comprising gelatin or hydroxyl propylmethyl cellulose.
16. The method of claim 1 , wherein the composition further comprises isopropyl myristate (IPM).
17. The method of claim 16 , wherein the composition comprises from about 1 weight percent to about 75 weight percent of the IPM.
18. The method of claim 16 , wherein the composition comprises:
from about 20 weight percent to about 90 weight percent of the SAIB;
from about 1 weight percent to about 8.6 weight percent of the CAB;
from about 1 weight percent to about 75 weight percent of the IPM; and
from about 20 weight percent to about 50 weight percent of the solvent.
19. The method of claim 18 , wherein the composition comprises from about 3 weight percent to about 7.8 weight percent of the CAB.
20. The method of claim 18 , wherein the composition comprises from 0.1 weight percent to 10 weight percent of the IPM.
21. The method of claim 18 , wherein the composition comprises:
from about 30 weight percent to about 70 weight percent of the SAIB; and
from about 25 weight percent to about 48 weight percent of the solvent.