Biomarkers for the identification of prostate cancer and methods of use
The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.
1. A method for treating a subject suspected of having an aggressive prostate cancer, the method comprising:
(i) obtaining a blood sample from a subject having prostate cancer;
(ii) isolating genomic DNA from the sample;
(iii) detecting the presence of a C allele at the rs2248490 SNP and a G allele at the rs15736 SNP in the WDR4 gene in the sample, wherein the presence of a C allele at the rs2248490 SNP and a G allele at the rs15736 SNP is associated with aggressive prostate cancer, and;
(iv) administering to the subject at least one cancer therapy for the treatment of prostate cancer.
2. The method of claim 1 , wherein the method further comprises:
(v) detecting -the allele present at at least one additional SNP in a gene, wherein the at least one additional SNP is rs362708 in the RELN gene.
3. The method of claim 2 , wherein the method step of (v) further comprises detecting the allele present at rs3817552 or rs764291 in the MYBPC1 gene.
4. The method of claim 3 , wherein the method of step (v) further comprises detecting the allele present at rs8546 in the NCOR2 gene.
5. The method of claim 1 , wherein the subject is African American.
6. The method of claim 1 , wherein the cancer therapy is selected from the group consisting of chemotherapy, hormone therapy, androgen therapy, radiation, surgery, vaccine therapy, immunotherapy and combinations thereof.
7. The method of claim 4 , wherein the method step of (iii) further comprises detecting the allele present at rs11911090 in the WDR4 gene.
8. The method of claim 1 , wherein the method step of (iii) comprises detecting the allele present of a SNP at rs3817552 or rs764291 in the MYBPC1 gene.
9. The method of claim 1 , wherein the method step of (iii) further comprises detecting the allele present at rs8546 in the NCOR2 gene.
10. The method of claim 1 , wherein the method step of (iii) further comprises detecting the allele present at rs3817552 in the MYBPC1 gene.
11. The method of claim 1 , wherein the method step of (iii) further comprises detecting the allele present at rs11911090 in the WDR4 gene.