Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
View Patent ↗The present invention relates to a crystalline form of N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide p-toluenesulfonate, the process for preparing the crystalline form thereof, and pharmaceutical compositions comprising the crystalline form thereof. This invention also relates to a method of using such a crystalline form in the treatment of hyperproliferative diseases in mammals, especially in humans.
1. A crystalline form of a compound of formula (I):
wherein the crystalline form is form C having:
a) an X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at about 7.20°, about 10.06°, about 17.40°, about 17.75°, about 18.65°, about 19.48° and about 20.13°; or
b) an X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at 7.20°±0.2°, 10.06°±0.2°, 17.40°±0.2°, 17.75°±0.2°, 18.65°±0.2°, 19.48°±0.2° and 20.13°±0.2°.
2. The crystalline form of claim 1 having an X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at about 7.20°, about 10.06°, about 14.96°, about 16.76, about 17.40°, about 17.75°, about 18.65°, about 19.48°, about 20.13°, about 20.90°, about 21.71°, about 22.69°, about 23.37°, about 24.40°, about 25.52°, about 26.29° and about 28.41°; or at 7.20°±0.2°, 10.06°±0.2°, 14.96±0.2°, 16.76±0.2°, 17.40°±0.2°, 17.75°±0.2°, 18.65°±0.2°, 19.48°±0.2°, 20.13°±0.2°, 20.90°±0.2°, 21.71°±0.2°, 22.69°±0.2°, 23.37°±0.2°, 24.40°±0.2°, 25.52°±0.2°,26.29°±0.2° and 28.41°±0.2°.
3. The crystalline form of claim 1 , wherein the X-ray powder diffraction pattern is substantially in accordance with that shown in FIG. 1 .
4. The crystalline form of claim 1 , wherein the crystalline form is substantially pure.
5. A pharmaceutical composition comprising the crystalline form of claim 1 and a pharmaceutically acceptable excipient, carrier, vehicle or a combination thereof.
6. The pharmaceutical composition of claim 5 further comprising a therapeutic agent.
7. The pharmaceutical composition of claim 6 , wherein the therapeutic agent is melphalan, cyclophosphamide, ifosfamide, busulfan, carmustine, lomustine, streptozocin, cisplatin, carboplatin, oxaliplatin, dacarbazine, temozolomide, procarbazine, methotrexate, fluorouracil, cytarabine, gemcitabine, mercaptopurine, fludarabine, vinblastine, vincristine, vinorelbine, paclitaxel, docetaxel, topotecan, irinotecan, etoposide, trabectedin, dactinomycin, doxorubicin, epirubicin, daunorubicin, mitoxantrone, bleomycin, mitomycin, ixabepilone, tamoxifen, flutamide, gonadorelin analogues, megestrol, prednisone, dexamethasone, methylprednisolone, thalidomide, interferon alfa, leucovorin, sirolimus, temsirolimus, everolimus, afatinib, alisertib, amuvatinib, apatinib, axitinib, bosutinib, bortezomib, brivanib, cediranib, cabozantinib, crenolanib, crizotinib, dabrafenib, dacomitinib, danusertib, dasatinib, dovitinib, erlotinib, foretinib, ganetespib, gefitinib, ibrutinib, icotinib, imatinib, iniparib, lapatinib, lenvatinib, linifanib, linsitinib, masitinib, momelotinib, neratinib, nilotinib, niraparib, oprozomib, olaparib, pazopanib, pegaptanib, pictilisib, ponatinib, quizartinib, radotinib, regorafenib, rigosertib, rucaparib, ruxolitinib, saracatinib, saridegib, sorafenib, sunitinib, tasocitinib, telatinib, tivantinib, tivozanib, tofacitinib, trametinib, vandetanib, veliparib, vemurafenib, vismodegib, volasertib, alemtuzumab, bevacizumab, brentuximabvedotin, catumaxomab, cetuximab, denosumab, gemtuzumab, ipilimumab, nimotuzumab, ofatumumab, panitumumab, ramucirumab, rituximab, tositumomab, trastuzumab, idelalisib, duvelisib, gilteritinib, buparlisib, taselisib, copanlisib, voxtalisib, pilaralisib, sonolisib, perifosine, alectinib, ibrutinib, pertuzumab, nintedanib, cobimetinib, temsirolimus, sirolimus, pixantrone or a combination thereof.