Synchronization of ion generation with cycling of a discontinuous atmospheric interface
The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
1. An online reaction monitoring system, the system comprising:
a reaction vessel comprising an outlet port;
a channel that extends from within the outlet port;
an electrode operably associated with a distal end of the channel, wherein the electrode is external to the channel and does not physically contact the channel or a liquid or vapor within the channel; and
a mass spectrometer.
2. The system according to claim 1 , wherein the electrode is positioned to inductively interact with a distal end of the channel.
3. The system according to claim 1 , wherein the reaction vessel comprises one or more inlet ports.
4. The system according to claim 3 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.
5. The system according to claim 1 , wherein the channel extends into the reaction vessel.
6. The system according to claim 1 , wherein the channel comprises one or more splitters.
7. The system according to claim 6 , wherein a first splitter withdraws a portion of a liquid from the channel.
8. The system according to claim 7 , wherein a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.
9. The system according to claim 1 , further comprising a heating element operably associated with the reaction vessel.
10. The system according to claim 1 , wherein the mass spectrometer is a miniature mass spectrometer.
11. An online reaction monitoring system, the system comprising:
a reaction vessel comprising an outlet port;
a channel that extends from within the outlet port;
an electrode positioned to inductively interact with a distal end of the channel, wherein the electrode is external to the channel and does not physically contact the channel or a liquid or vapor within the channel and the electrode produces a pulsed current; and
a mass spectrometer.
12. The system according to claim 11 , wherein the pulsed current is a pulsed DC current.
13. The system according to claim 11 , wherein the reaction vessel comprises one or more inlet ports.
14. The system according to claim 13 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.
15. The system according to claim 11 , wherein the channel extends into the reaction vessel.
16. The system according to claim 11 , wherein the channel comprises one or more splitters.
17. The system according to claim 16 , wherein a first splitter withdraws a portion of a liquid from the channel.
18. The system according to claim 17 , wherein a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.
19. The system according to claim 11 , further comprising a heating element operably associated with the reaction vessel.
20. The system according to claim 11 , wherein the mass spectrometer is a miniature mass spectrometer.