Automatic aseptic sampling valve for sampling from enclosed containers
A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
1. An aseptic automatic fluid sampling system, comprising:
a variable volume reservoir, wherein the variable volume reservoir comprises diaphragm pump, moveable between a first configuration that defines a first
volume for receiving a fluid sample from a container and a second configuration that defines a second volume, the first volume being larger than the second volume, the variable volume reservoir comprising a variable volume reservoir inlet through which the fluid sample is received into the variable volume reservoir, and a variable volume reservoir outlet through which the fluid sample is discharged from the variable volume reservoir;
a sample collection valve moveable between an open configuration and a closed
configuration, the sample collection valve being coupled to a fluid outlet of the container;
a sample delivery flow path beginning at the sample collection valve and extending downstream to the inlet of the variable volume reservoir, the sample collection valve being in fluid connection with the inlet of the variable volume reservoir when the sample collection valve is in the open configuration;
a three-way valve upstream of the sample collection valve, the three-way valve being operable at a first position that permits the flow of a sanitizing fluid through the three-way valve, the three-way valve being operable at a second position that permits the flow of a purge fluid through the three-way valve, forming a purge fluid delivery flow path; and the three-way valve being operable at a third position that restricts the flow of both the sanitizing fluid and of the purge fluid through the three-way valve;
the three-way valve being positioned to receive the sanitizing fluid from a sanitizing fluid source separate from the container;
an outlet valve positioned downstream of the variable volume reservoir outlet, the outlet valve being moveable between an open configuration and a closed configuration; wherein the sample collection valve is upstream of the variable volume reservoir; and
a sanitizing fluid flow path beginning at the three-way valve and extending downstream at least between the three-way valve and the inlet of the variable volume reservoir, the sanitizing fluid flow path completely overlapping the sample delivery flow path,
wherein movement of the variable volume reservoir from the first configuration to the second configuration causes the fluid sample to be drawn aseptically and discharged from the variable volume reservoir, and
wherein, when the sample collection valve is in the closed configuration and the three-way valve is in the first position, the sanitizing fluid flow path extends downstream at least from the three-way valve to the sample collection valve and from the sample collection valve to the inlet of the variable volume reservoir, and the sample collection valve is in fluid connection with the inlet of the variable volume reservoir so the sample delivery flow path may be sanitized frequently.
2. The aseptic automatic fluid sampling system of claim 1 , wherein, when the sample collection valve is in the closed configuration and the three-way valve is in the second position, the purge fluid delivery flow path extends at least from the three-way valve to the sample collection valve and from the sample collection valve to the variable volume reservoir.
3. The aseptic automatic fluid sampling system of claim 1 , further comprising a control valve positioned downstream of the outlet valve.
4. The aseptic automatic fluid sampling system of claim 3 , wherein the control valve comprises a variable back-pressure regulator.
5. The aseptic automatic fluid sampling system of claim 3 , wherein the control valve comprises a thermostatically-controlled valve.
6. The aseptic automatic fluid sampling system of claim 1 , wherein the variable volume reservoir comprises a flexible diaphragm member and a housing with a first area and a second area, the flexible diaphragm member being configured to move between a first position where a first surface of the flexible diaphragm member contacts the first area of the housing and a second position where a second surface of the flexible diaphragm member contacts the second area of the housing.
7. The aseptic automatic fluid sampling system of claim 6 , wherein the first surface of the flexible diaphragm member is generally opposite the second surface of the flexible diaphragm member.
8. The aseptic automatic fluid sampling system of claim 6 , wherein the flexible diaphragm member comprises a generally spherical housing and the first area is a first half of the generally spherical housing and the second area is a second half of the generally spherical housing, wherein the second surface contacts the second half of the generally spherical housing when in the second position, the flexible diaphragm member being generally inverted when in the second position, relative to its orientation when in the first position.
9. The aseptic automatic fluid sampling system of claim 1 , wherein the sample collection valve comprises a valve stem with a tapered sealing member that moves from a first position when the sample collection valve is in the open configuration to a second position when the sample collection valve is in the closed configuration, wherein a portion of the valve stem extends into the sanitizing fluid flow path when the sample collection valve is in the second position.
10. The aseptic automatic fluid sampling system of claim 1 , wherein the sample collection valve, and the three-way valve are contained within a single housing.