IP Library Granted Patent US 10,761,083
Granted Patent B2
US 10,761,083 · App. 15/357,048 · Granted Sep 1, 2020

Sample dispenser including an internal standard and methods of use thereof

Inventors: Zheng Ouyang (West Lafayette, IN); He Wang (West Lafayette, IN); Nicholas E. Manicke (West Lafayette, IN); Robert Graham Cooks (West Lafayette, IN); Qian Yang (West Lafayette, IN); Jiangjiang Liu (West Lafayette, IN)
Assignee: Purdue Research Foundation
G01N33/492G01N1/28G01N1/286G01N33/48714G01N33/48785G01N33/491H01J49/0009H01J49/0027H01J49/16G01N1/10G01N2001/2893
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Quick Facts
Patent No.
US 10,761,083
App. No.
15/357,048
Granted
Sep 1, 2020
Kind
B2
Abstract

The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.

Claims (8)

1. A system for analyzing a sample comprising:

a probe comprising at least one porous substrate connected to a high voltage source such that an electric field is generated at a tip of the at least one porous substrate, wherein the at least one porous substrate is discrete from a flow of solvent and at least a portion of the at least one porous substrate comprises an internal standard; and

a mass spectrometer, wherein the system is configured such that ions generated by the probe are transferred to an inlet of the mass spectrometer without pneumatic assistance.

2. The system according to claim 1 , wherein the internal standard coats at least a portion of the at least one porous substrate.

3. The system according to claim 1 , wherein the internal standard impregnates at least a portion of the at least one porous substrate.

4. The system according to claim 1 , further comprising a solvent applied to the substrate.

5. The system according to claim 4 , wherein the solvent assists transport of a sample through the at least one porous substrate.

6. The system according to claim 1 , wherein the mass spectrometer is a handheld mass spectrometer.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 12, 2020
From: COOKS, R. GRAHAM; OUYANG, ZHENG; LIU, JIANGJIANG; WANG, HE; MANICKE, NICHOLAS; YANG, QIAN
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 052633/0143 →
CONFIRMATORY LICENSE Recorded Sep 12, 2017
From: PURDUE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 043820/0732 →
Continuity (7)
Continuation 13784094 · Mar 4, 2013
Continuation In Part 13265110
Provisional Application 61608944 · Mar 9, 2012
Provisional Application 61308332 · Feb 26, 2010
Provisional Application 61246707 · Sep 29, 2009
Provisional Application 61174215 · Apr 30, 2009
Related Publication 20170082604A1 · Mar 23, 2017