IP Library › Granted Patent US 10,029,003
Granted Patent B2
US 10,029,003 · App. 15/359,333 · Granted Jul 24, 2018

Methods and materials for treating cancer

Inventors: Jose S. Pulido (Rochester, MN); Richard G. Vile (Rochester, MN); Timothy J. Kottke (Oronoco, MN); Alan A. Melcher (Leeds, GB); Peter Selby (Leeds, GB)
Assignees: Mayo Foundation for Medical Education and Research; University of Leeds
A61K39/0011A61K48/00A61K2039/53
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Quick Facts
Patent No.
US 10,029,003
App. No.
15/359,333
Granted
Jul 24, 2018
Kind
B2
Abstract

This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.

Claims (5)

1. A method of treating melanoma within a mammal, wherein said method comprises administering to said mammal a composition comprising nucleic acid encoding melanoma antigens consisting of an N-RAS antigen, a TYRP1 antigen, and a CYT-C antigen.

2. The method of claim 1 , wherein said nucleic acid encoding N-RAS antigen is a VSV-N-RAS virus.

3. The method of claim 1 , wherein said N-RAS antigen, said TYRP1 antigen, and said CYT-C antigen are VSV-expressed.

4. The method of claim 1 , wherein said nucleic acid encoding TYRP1 antigen is a VSV-TYRP1 virus.

5. The method of claim 1 , wherein said nucleic acid encoding CYT-C antigen is a VSV-CYT-C virus.

Assignments (3)
CONFIRMATORY LICENSE Recorded May 12, 2017
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042456/0581 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 9, 2017
From: PULIDO, JOSE S.; VILE, RICHARD G.; KOTTKE, TIMOTHY J.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 042304/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 9, 2017
From: MELCHER, ALAN; SELBY, PETER
To: UNIVERSITY OF LEEDS
Reel/Frame 042304/0365 →
Continuity (3)
Division 14385240
Provisional Application 61611387 · Mar 15, 2012
Related Publication 20170143813A1 · May 25, 2017