NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS

1 . A method for the treatment of nicotine addiction or smoking cessation comprising the administration of a compound of Formula I:

wherein

each of R 1 and R 2 individually is H, C 1-6 alkyl, or aryl-substituted C 1-6 alkyl, or R 1 and R 2 combine with the nitrogen atom to which they are attached to form a 3- to 8-membered ring, which ring may be optionally substituted with C 1-6 alkyl, aryl, C 1-6 alkoxy, or aryloxy substituents;

R 3 is H, C 1-6 alkyl, or C 1-6 alkoxy-substituted C 1-6 alkyl;

each of R 4 , R 5 , R 6 , and R 7 individually is H, C 1-6 alkyl, or C 1-6 alkoxy;

L 1 is a linker species selected from the group consisting of CR 8 R 9 , CR 8 R 9 CR 10 R 11 , and O;

L 2 is a linker species selected from the group consisting of CH 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 , and CH 2 CH 2 CH 2 CH 2 ;

each of R 8 , R 9 , R 10 , and R 11 individually is hydrogen or C 1-6 alkyl; and

the dashed line indicates an optional double bond;

or a pharmaceutically acceptable salt thereof.

2 . The method of claim 1 , wherein the disease or condition is IBS-D, GAB, depression, major depressive disorder, or hypertension.

3 . A method for the treatment of nicotine addiction or smoking cessation comprising the administration of a compound

or a pharmaceutically acceptable salt thereof.