Granted Patent
B2
US 9,878,992 · App. 15/366,981 · Granted Jan 30, 2018
GDF-8 inhibitors
Inventors:
Somasekhar Bhamidipati (Foster City, CA); Marina Gelman (San Francisco, CA); Pingyu Ding (Foster City, CA); Rajinder Singh (Belmont, CA); Jeffrey Clough (Redwood City, CA); Todd Kinsella (Redwood City, CA); Donald Payan (Hillsborough, CA)
Assignee:
RIGEL PHARMACEUTICALS, INC.
C07D401/04C07D213/26C07D401/14C07D405/04C07D405/14C07D413/04C07D417/04C07D417/14C07D453/02C07D471/04C07D487/04C07D498/04C07D513/04C07F9/65038
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Abstract
Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R 1 , R 2 , R 5 , R 6 , X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.
Claims (3)
1. A compound of the structural formula
or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 wherein the salt is a pharmaceutically acceptable salt is the formic acid salt.
Assignments (2)
SECURITY INTEREST
Recorded Aug 25, 2022
From: RIGEL PHARMACEUTICALS, INC.
To: MIDCAP FINANCIAL TRUST
Reel/Frame 061327/0712 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 2, 2016
From: BHAMIDIPATI, SOMASEKHAR; GELMAN, MARINA; DING, PINGYU; SINGH, RAJINDER; CLOUGH, JEFFREY; KINSELLA, TODD; PAYAN, DONALD
To: RIGEL PHARMACEUTICALS, INC.
Reel/Frame 040495/0261 →
Continuity (4)
Provisional Application
61710449
· Oct 5, 2012