VMAT INHIBITORY COMPOUNDS

1 - 48 . (canceled)

49 . A compound with the formula:

wherein X is a substituted or unsubstituted 5- or 6-membered aryl or substituted or unsubstituted 5- or 6-membered heteroaryl,

Z is N or CH,

m is 1, 2, or 3,

Ar is a substituted or unsubstituted 5- or 6-membered aryl or a substituted or unsubstituted 5- or 6-membered heteroaryl,

R is H, ethyl ester, isopropyl ester, —C(O)-alkyl, or substituted or unsubstituted 5-membered heteroaryl,

Y is H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, mixture of stereoisomers, crystal form, or isotopomer thereof.

50 . The compound of claim 49 , wherein R is ethyl ester or —C(O)-alkyl.

51 . The compound of claim 49 , wherein Ar is phenyl, substituted phenyl, pyrrolyl, substituted pyrrolyl, pyridinyl, substituted pyridinyl, thiophene-yl, substituted thiophene-yl, or [1,4]-dioxinyl.

52 . The compound of claim 49 , wherein the structure of the compound is:

wherein A 1 , A 2 , A 3 , and A 4 , are independently H, alkyl, substituted alkyl, aryl, substituted aryl, halo, alkoxy, haloalkyl, haloalkoxy, ester, keto, hydroxyl, amino, substituted amino, amido, nitro, methyl, ethyl, isopropyl, [1,4]dioxin-5-yl, fluoro, chloro, trifluoromethyl, amino, dimethylamino, methylamido, azo, benzyl, 2-phenyl ethyl, pyrrolyl, ethyl ester, 1-hydroxyethyl, methoxy, trifluoromethoxy, or tert-butoxycarbonylamino.

53 . The compound of claim 52 , wherein A 1 and A 2 are H, and A 3 and A 4 are independently H, fluoro, or trifluoromethyl.

54 . The compound of claim 49 , wherein the structure of the compound is:

and

wherein A 3 is halo or fluoro, and m is 2 or 3.

55 . The compound of claim 49 , wherein the structure of the compound is:

wherein Y 1 is H, methyl, ethyl, or 2-benzylethyl,

wherein Y 2 is H or halo, and

wherein A 3 and A 4 are independently H or halo.

56 . The compound of claim 49 , wherein the structure of the compound is:

wherein A 1 , A 2 , A 3 , and A 4 are independently H, halo, or haloalkyl, and wherein Y is H or alkyl.

57 . The compound of claim 56 , wherein Y is H, A 1 and A 2 are H, and A 3 and A 4 are independently H, fluoro, or trifluoromethyl.

58 . A compound of the Formula I:

wherein X is a substituted or unsubstituted 5- or 6-membered aryl or substituted or unsubstituted 5- or 6-membered heteroaryl,

Z is N or CH,

m is 1, 2, or 3,

Ar is a substituted or unsubstituted 5- or 6-membered aryl or a substituted or unsubstituted 5- or 6-membered heteroaryl,

R is ethyl ester, isopropyl ester, —C(O)-alkyl, or substituted or unsubstituted 5-membered heteroaryl,

Y is H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

wherein the bond between the carbon atoms bearing Ar and R is a single or double bond,

or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, mixture of stereoisomers, crystal form, or isotopomer thereof.

59 . The compound of claim 58 , wherein R is ethyl ester or —C(O)-alkyl.

60 . The compound of claim 58 , wherein Ar is phenyl, substituted phenyl, pyrrolyl, substituted pyrrolyl, pyridinyl, substituted pyridinyl, thiophene-yl, substituted thiophene-yl, or [1,4]-dioxinyl.

61 . The compound of claim 58 , wherein the structure of the compound is:

wherein A 1 , A 2 , A 3 , and A 4 , are independently H, alkyl, substituted alkyl, aryl, substituted aryl, halo, alkoxy, haloalkyl, haloalkoxy, ester, keto, hydroxyl, amino, substituted amino, amido, nitro, methyl, ethyl, isopropyl, [1,4]dioxin-5-yl, fluoro, chloro, trifluoromethyl, amino, dimethylamino, methylamido, azo, benzyl, 2-phenyl ethyl, pyrrolyl, ethyl ester, 1-hydroxyethyl, methoxy, trifluoromethoxy, or tert-butoxycarbonylamino.

62 . The compound of claim 61 , wherein A 1 and A 2 are H, and A 3 and A 4 are independently H, fluoro, or trifluoromethyl.

63 . The compound of claim 58 , wherein the structure of the compound is:

wherein A 3 is halo or fluoro, and m is 2 or 3.

64 . The compound of claim 58 , wherein the structure of the compound is:

wherein Y 1 is H, methyl, ethyl, or 2-benzylethyl,

wherein Y 2 is H or halo, and

wherein A 3 and A 4 are independently H or halo.

65 . The compound of claim 58 , wherein the structure of the compound is:

wherein A 1 , A 2 , A 3 , and A 4 are independently H, halo, or haloalkyl, and

wherein Y is H or alkyl.

66 . The compound of claim 65 , wherein Y is H, A 1 and A 2 are H, and A 3 and A 4 are independently H, fluoro, or trifluoromethyl.

67 . The compound of claim 58 , wherein the structure of the compound is:

68 . A method for treating a subject having a methamphetamine (MA) addiction, comprising:

Administering to the subject a therapeutically effective amount of a pharamaceutical composition comprising compound with the formula:

wherein X is a substituted or unsubstituted 5- or 6-membered aryl or substituted or unsubstituted 5- or 6-membered heteroaryl,

Z is N or CH,

m is 1, 2, or 3,

Ar is a substituted or unsubstituted 5- or 6-membered aryl or a substituted or unsubstituted 5- or 6-membered heteroaryl,

R is ethyl ester, isopropyl ester, —C(O)-alkyl, or substituted or unsubstituted 5-membered heteroaryl,

Y is H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

wherein the bond between the carbon atoms bearing Ar and R is a single or double bond,

or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, mixture of stereoisomers, crystal form, or isotopomer thereof.