Implant comprising nonbiologic portion and biologic portion
In one aspect, an implant for replacing subject tissue includes a nonbiologic portion and a biologic portion grown on the nonbiologic portion. The biologic portion may be grown on the nonbiologic portion before being implanted in the subject. The nonbiologic portion may comprise a porous metal substrate (e.g., scaffolding). The nonbiologic portion may be formed by 3D printing (i.e., additive manufacturing). The nonbiologic portion may be patient-specific. A robot may be used to shape the implant before implantation and/or to shape bone being replaced/resurfaced.
1. An implant for being implanted in a subject, the implant comprising:
a three-dimensional (3D) printed shell configured to be implanted in an organ having a first tissue with a first tissue porosity and a second tissue with a second tissue porosity, the shell comprising a nonbiologic material that is formed by 3D printing the shell having a first porous region having a first porosity corresponding with the first tissue porosity and a second porous region having a second porosity corresponding with the second tissue property, wherein the first porous region overlies the second porous region;
a first type of tissue ingrown by incubation into pores of the first porous region of the shell, wherein the first type of tissue comprises cartilage tissue;
a second type of tissue different from the first type of tissue ingrown by incubation into pores of the second porous region of the shell, wherein the second type of tissue comprises bone.
2. An implant as set forth in claim 1 wherein the shell has a density corresponding with a tissue density of the subject.
3. An implant as set forth in claim 1 further comprising a tissue attachment structure connected to the shell.
4. An implant as set forth in claim 1 wherein the shell defines a passage for receiving a body part of the subject.
5. An implant as set forth in claim 1 wherein the shell comprises a metal.
6. An implant as set forth in claim 5 wherein the shell comprises a metal foam.
7. An implant as set forth in claim 1 wherein the implant is shaped and arranged for being press fit into a hole in tissue of the subject.
8. An implant as set forth in claim 1 wherein the implant has first and second ends and sides that taper between the first and second ends.
9. An implant as set forth in claim 1 further comprising at least one anchoring projections extending from the shell and configured to anchoring the implant in the subject.
10. An implant as set forth in claim 1 , wherein the first porous region of the shell has a first thickness configured to match a first tissue thickness of the first type of tissue having the first porosity and the second porous region of the shell has a second thickness configured to match a second tissue thickness of the second type of tissue having the second porosity.
11. An implant as set forth in claim 10 , wherein the shell has proximal and distal ends, the first porous region of the shell extending from the proximal end to a position intermediate of the proximal and distal ends, the second porous region of the shell extending from the first porous region at the position intermediate of the proximal and distal ends to the distal end.
12. An implant as set forth in claim 1 , wherein pores of the first porous region are in communication with pores of the second porous region.