Binding inhibitor between TCTP dimer type IGE-dependent histamine releasing factor and receptor thereof, and use thereof
The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structural region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, bronchitis, chronic obstructive pulmonary disease, bronchiectasis, rhinitis, atopic dermatitis, hives (urticaria), hay fever, conjunctivitis, and anaphylaxis; inflammatory diseases such as bronchitis, pneumonia, arthritis, nephritis, psoriasis, dermatitis, Crohn's disease, enteritis, gingivitis, arteriosclerosis, coronary arteritis, hepatitis, Behcet's disease, bladder cancer, prostatitis, pyelonephritis, glomerulonephritis, osteomyelitis, thyroiditis, uveitis, abdominal cavity inflammation, meningitis, pulmonary fibrosis and rheumatoid arthritis; and malaria, and a method for screening for the HRF-related diseases.
1. A flexible loop (FL) domain peptide, wherein:
the amino acid sequence of the FL domain peptide consists of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4;
and
wherein the peptide is modified with an N-terminal acetylation, a C-terminal amidation, or both.
2. The peptide of claim 1 , wherein the amino acid sequence of the peptide consists of SEQ ID NO: 1.
3. The peptide of claim 2 , wherein the peptide comprises an N-terminal acetylation and a C-terminal amidation.
4. The peptide of claim 1 , wherein the amino acid sequence of the peptide consists of SEQ ID NO: 2.
5. The peptide of claim 4 , wherein the peptide comprises an N-terminal acetylation and a C-terminal amidation.
6. The peptide of claim 1 , wherein the amino acid sequence of the peptide consists of SEQ ID NO: 3.
7. The peptide of claim 6 , wherein the peptide comprises an N-terminal acetylation and a C-terminal amidation.
8. The peptide of claim 1 , wherein the amino acid sequence of the peptide consists of SEQ ID NO: 4.
9. The peptide of claim 8 , wherein the peptide comprises an N-terminal acetylation and a C-terminal amidation.
10. A method for treating one or more diseases selected from the group consisting of allergic diseases and rheumatoid arthritis, comprising the step of administering the peptide of claim 1 .
11. The method of claim 10 , wherein the allergic disease includes one or more of rhinitis, asthma, anaphylaxis, or atopy.
12. The method of claim 10 , wherein the peptide comprises an N-terminal acetylation and a C-terminal amidation.