Customizable radioactive carriers and loading system
Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.
1. A method comprising:
providing a loading device having
a planar support surface sized to receive a sheet of collagen; and
at least one side wall including at least one guide channel sized and configured to receive and direct a guide tool;
positioning the sheet of collagen on the planar support surface;
inserting a first end of the guide tool through at least one of the at least one guide channel and into a side of the sheet of collagen; and
moving a cylindrical radionuclide seed into the sheet of collagen to embed the cylindrical radionuclide seed between a top surface and a bottom surface of the sheet of collagen.
2. The method of claim 1 , wherein sides of the sheet of collagen are less than seven millimeters in thickness between a top and bottom surface.
3. The method of claim 1 , wherein the at least one side wall is a proximal wall of the loading device.
4. The method of claim 3 , the loading device further having a lid configured to engage with a top surface of the side wall, the lid having at least one exit guide channel positioned to receive the guide tool after passing through the sheet of collagen.
5. The method of claim 4 , wherein the at least one exit guide channel is on a distal end of the loading device.
6. A method comprising:
providing a loading device having a planar support surface sized to receive a collagen substrate having a thickness of between about one millimeter and seven millimeters between a top surface and a bottom surface, the loading device further comprising at least one guide channel within a side wall adjacent the planar support surface, wherein the collagen substrate comprises one or more sections each configured to receive one or more radionuclide seeds;
positioning the collagen substrate on the planar support surface;
for each of the one or more sections,
inserting a radionuclide seed through at least one of the guide channels and into the section such that the radionuclide seed is embedded at an offset position between the top surface and the bottom surface of the collagen substrate.
7. The method of claim 6 , further comprising:
separating the one or more sections of the collagen substrate into corresponding one or more separately implantable radionuclide carriers.
8. The method of claim 6 , wherein the thickness of the collagen substrate is four millimeters.
9. The method of claim 6 , wherein said inserting the radionuclide seed is performed manually.
10. The method of claim 6 , wherein said inserting the radionuclide seed is performed automatically.
11. The method of claim 6 , wherein said inserting the radionuclide seed comprises:
inserting a first radionuclide seed through a first of the guide channels and into a first section of the collagen substrate, and
inserting a second radionuclide seed through a second of the guide channels and into a second section of the collagen substrate.
12. The method of claim 6 , wherein a strand of radioactive seeds are attached to a guide tool and said inserting comprises moving the guide tool through the at least one of the guide channels.
13. The method of claim 12 , wherein the guide tool comprises a needle.