Compounds and methods for inhibiting vacuolar ATPase
A compound of Formula II, is provided. R 1 , R 2 and R 3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino or hydroxyl. X is either F, Cl, Br, I or CN. Y is either N or CH. Compositions that include Formula II can be used to inhibit vacuolar H + ATPase.
1. A compound of Formula II,
wherein R 1 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl,
R 2 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl,
R 3 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl,
X is selected from the group consisting of F, Br, I and CN,
and Y is N or CH.
2. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is F, and Y is N.
3. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is Br, and Y is N.
4. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is I, and Y is N.
5. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is CN, and Y is N.
6. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is F, and Y is CH.
7. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is Br, and Y is CH.
8. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is I, and Y is CH.
9. The compound of claim 1 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is CN, and Y is CH.
10. A method of inhibiting vacuolar H + ATPase comprising treating vacuolar H + ATPase with a composition comprising a compound of Formula II,
wherein R 1 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl,
R 2 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl,
R 3 is selected from the group consisting of hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino and hydroxyl,
X is selected from the group consisting of F, Cl, Br, I and CN,
and Y is N or CH.
11. A method of inhibiting vacuolar H + ATPase comprising treating vacuolar H + ATPase with a composition comprising the compound of claim 10 , wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is hydrogen, X is Cl, and Y is N.
12. The method of claim 10 , wherein a catalytic subunit A of the vacuolar H + ATPase is targeted.
13. The method of claim 11 , wherein a catalytic subunit A of the vacuolar H + ATPase is targeted.