6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor

1. A compound of the formula I:

wherein:

R 1 is selected from the group consisting of:

(1) hydrogen;

(2) —C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, fluoro, —CN, —O—C 1-6 alkyl, C 3-6 cycloalkyl, bicycle[1.1.1]pentane, tetrahydrofuranyl, phenyl, pyridyl, oxazolyl, —NH 2 , —NH(—C 1-6 alkyl), —N(—C 1-6 alkyl) 2 , and —N(C═O)—C 1-6 alkyl, wherein the C 1-6 alkyl or C 3-6 cycloalkyl is unsubstituted or substituted with substituents selected from the group consisting of: fluoro, cyano, CF 3 , C 1-6 alkyl or —O—C 1-6 alkyl;

(3) a phenyl, heteroaryl or heterocyclyl ring, wherein the phenyl, heteroaryl or heterocyclyl ring is substituted with one or more R 1a , R 1b and R 1c , wherein R 1a , R 1b and R 1c are independently selected from the group consisting of:

(a) hydrogen,

(b) hydroxy,

(c) halogen,

(d) C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, cyclopropyl, cyclobutyl, cyclopentyl, azetidinyl, fluoro, —OCH 3 , —OCH 2 CH 2 OCH 3 , —(C═O)—C 1-6 alkyl, —NH 2 , —NH(C 1-6 alkyl), and —N(C 1-6 alkyl) 2 ,

(e) —O—C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, cyclopropyl, cyclobutyl, cyclopentyl, azetidinyl, fluoro, —OCH 3 , —NH 2 , —NH(C 1-6 alkyl), —N(C 1-6 alkyl) 2 , and —NH(C═O)(C 1-6 alkyl),

(f) C 3-6 cycloalkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: C 1-6 alkyl, hydroxy, cyclopropyl, cyclobutyl, cyclopentyl, azetidinyl, fluoro, —OCH 3 , —NH 2 , —NH(C 1-6 alkyl), and —N(C 1-6 alkyl) 2 ,

(g) —NH 2 ,

(h) —NH(C 1-6 alkyl),

(i) —NH(C 2-6 alkyl)-OH,

(j) —N(C 1-6 alkyl) 2 ,

(k) —SO 2 —C 1-6 alkyl,

(l) —(C═O)H,

(m) —(C═O)—C 1-6 alkyl,

(n) —(C═O)O—C 1-6 alkyl, and

(o) —CN;

R 2 and R 3 are independently selected from the group consisting of:

(1) hydrogen,

(2) fluoro,

(3) hydroxy, and

(4) —CH 3 ;

R 4 is hydrogen or methyl, and R 6 is hydrogen or methyl, or R 4 and R 6 are joined together with a —(CH 2 ) 2 — to form a bridged ring with the piperidine ring to which they are attached;

R 5 is hydrogen, or where R 2 is hydrogen, R 3 and R 5 may be joined together with a —(CH 2 )— to form a bridged ring with the piperidine ring to which they are attached;

R 7 and R 8 are independently selected from the group consisting of:

(1) hydrogen,

(2) C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, fluoro, and —OCH 3 ,

(3) —CH═CH 2 ,

(4) cyclopropyl,

(5) -fluoro,

(6) -chloro,

(7) -bromo,

(8) —CN,

(9) —(C═O)H, and

(10) —(C═O)O—C 1-6 alkyl;

R 9 is selected from the group consisting of:

(1) hydrogen,

(2) —C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, methoxy, fluoro, —C(C═O)O—C 1-6 alkyl, —NH 2 , —NH(C 1-6 alkyl), —N(C 1-6 alkyl) 2 , —C(C═O)NH 2 , —C(C═O)OH, oxetanyl, or pyridyl;

(3) —C 3-6 cycloalkyl,

(4) —C(C═O)O—C 1-6 alkyl, and

(5) —P(O)(OH) 2 ;

each of R 10 and R 11 is independently selected from the group consisting of:

(1) hydrogen,

(2) —OH,

(3) —CH 3 ,

(4) —CH 2 OH,

(5) —CH 2 CH 2 OH, and

(6) —C(CH 3 ) 2 OH,

or R 10 and R 11 taken together form a cyclopropyl group, a ═CH 2 group or a keto group;

or a pharmaceutically acceptable salt thereof; with the proviso that the compound is other than:

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro,5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

3-methyl-2-(4-4((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((5-methylpyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-methyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]poyridin-5-one;

2-[4-(1,3-dihydro-2-benzofuran-5-yloxy)piperidin-1-yl]-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3,4-dimethyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-3,4-dimethyl-2-(4-phenoxylpiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-3,4-dimethyl-2-(4-((1-methycyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one; or

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of: benzodioxolyl, benzoimidazolyl, benzoxazolyl, benzoxazinone, benzoxazolone, benzothiazolyl, chromanyl, cyclopentapyridinyl, dihydrobenzo[1,4]dioxinyl, dihydrobenzofuranyl, dihydrobenzo[1,4]oxazinyl, dihydrofuropyridinyl, dihydroisobenzofuranyl, dihydroisoquinolinone, dihydropyranopyridinyl, dihydroimidazopyridine, dihydropyrido[1,4]oxazinyl, dihydroquinolinone, indazolyl, indanyl, indolyl, isochromanone, isobenzofuranone, isochromanyl, isoindolinyl, isoxazolyl, oxoisoindolinyl, phenyl, pyrazolopyridinyl, pyrazolyl, pyridyl, pyrrolopyridinyl, pyrimidinyl, quinolinone, quinolinyl, tetrahydrofuranyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, and tetrahydropyranyl, which is substituted with one or more R 1a , R 1b and R 1c .

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is phenyl or pyridyl, which is substituted with one or more R 1a , R 1b and R 1c , wherein R 1a , R 1b and R 1c are independently selected from the group consisting of

(a) hydrogen,

(b) hydroxyl,

(c) halogen,

(d) C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, fluoro, and —OCH 3 ,

(e) —O—C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from the group consisting of: hydroxy, fluoro, and —OCH 3 ,

(g) —CN.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is phenyl, which is unsubstituted or substituted with —CN.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is pyridyl, which is unsubstituted or substituted with —OCH 3 .

6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is selected from the group consisting of:

(1) hydrogen,

(2) methyl,

(3) ethyl,

(4) —CH 2 OH,

(5) —CH 2 F,

(6) —CHF 2 ,

(7) —CF 3 ,

(8) —CH═CH 2 ,

(9) cyclopropyl,

(10) -fluoro,

(11) -chloro,

(12) -bromo,

(13) —CN,

(14) —(C═O)H, and

(15) —(C═O)O—C 1-6 alkyl.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 8 is selected from the group consisting of:

(1) hydrogen,

(2) methyl,

(3) ethyl,

(4) —CH 2 OH,

(5) —CH 2 F,

(6) —CHF 2 ,

(7) —CF 3 , and

(8) —(C═O)O—C 1-6 alkyl.

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 9 is selected from the group consisting of:

(1) hydrogen, and

(2) —C 1-6 alkyl, which is unsubstituted or substituted with hydroxy, methoxy, 1-3 fluoro.

10. A compound which is selected from the group consisting of:

2-((3R,4R)-4-((6-methoxypyridin-3-yl)oxy)-3-methylpiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4S)-4-((6-methoxypyridin-3-yl)oxy)-3-methylpiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(((trans)-2-(trifluoromethyl)cyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(difluoromethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-((3S,4S)-3-fluoro-4-((1-methyl cyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((cis-3-fluoro-1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-((3S,4R)-4-((1H-indazol-5-yl)oxy)-3-fluoropiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclopropylmethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2-cyclopropyl-3-oxoisoindolin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(3,6-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-(4-((1H-indazol-5-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(3,6,7-trimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-(4-((1H-indazol-5-yl)oxy)piperidin-1-yl)-3,6,7-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(3,6,7,7-tetramethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6,7-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6,7,7-tetramethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(((3R,4S)-3-fluoro-1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

3-(((3S,4S)-3-fluoro-1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

3-(((3R,4R)-3-fluoro-1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

3-methyl-2-(4-((1,2,3,4-tetrahydroquinolin-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4S)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4S)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1H-indol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-methyl-1H-indol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-((1-(3,6,7-trimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

(S)-3-((1-(3,6,7-trimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-((3S,4R)-4-((6-methoxypyridin-3-yl)oxy)-3-methylpiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4S)-4-((6-methoxypyridin-3-yl)oxy)-3-methylpiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-3-fluoro-4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3,6-dimethyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-ethoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-phenoxypiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

1-(((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)methyl)cyclopropane-1-carbonitrile;

2-(4-((6-cyclobutoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-4-yl)oxy)-3-fluoropiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((tetrahydrofuran-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((tetrahydro-2H-pyran-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(((3R,4R)-3-hydroxy-1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

3-(((3S,4S)-3-hydroxy-1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-(4-((2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(((3S,4R)-1-(3,6-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-3-fluoropiperidin-4-yl)oxy)benzonitrile;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-methoxyphenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(3-(methylsulfonyl)phenoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)-3-fluoropiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)nicotinonitrile;

2-(4-(3-methoxyphenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(2-ethoxyethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-ethoxypiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(2-methoxyethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(3-(methoxymethyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(3-((2-methoxyethoxy)methyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-3-fluoro-4-((6-(2-methoxyethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4S)-3-fluoro-4-((6-(2-methoxyethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-isopropoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(benzyloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-fluorocyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)-3-fluoropiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(2-(1-methylcyclopropyl)ethoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methyl-3-oxoisoindolin-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(pyridin-3-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methylbenzo[d]oxazol-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(3-fluorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-fluorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(2-chlorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(3-chlorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(2-fluorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-chlorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(pyridin-4-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(m-tolyloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(o-tolyloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(benzo[d]oxazol-5-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(3,4-difluorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(3-chloro-4-methylphenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(p-tolyloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

4-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)picolinonitrile;

2-(4-(isoxazol-3-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl-5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)picolinate

3-methyl-2-(4-((6-(trifluoromethyl)pyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(benzo[d]oxazol-6-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2-methoxypyridin-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-fluoropyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(quinolin-7-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

4-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)picolinonitrile;

3-((1-(3-ethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-(4-((2-methoxypyrimidin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(3,4-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

3-((endo-8-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)oxy)benzonitrile;

3-((exo-8-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)oxy)benzonitrile;

2-(endo-3-((6-methoxypyridin-3-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(exo-3-((1-methyl-1H-indazol-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(exo-3-((6-methoxypyridin-3-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(endo-3-((1-methyl-1H-indazol-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-(trifluoromethoxy)pyridin-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5-fluoropyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-aminopyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(azetidin-1-yl)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(dimethylamino)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-fluoro-3-methylphenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((3-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl-5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)nicotinate;

2-(4-(chroman-7-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5,6-dimethylpyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxy-5-methylpyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(chroman-6-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((3-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-3,4-dihydroquinolin-2(1H)-one;

2-(4-(3,4-dimethylphenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-oxoisochroman-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methylbenzo[d]thiazol-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methylbenzo[d]oxazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((6-(trifluoromethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((4,4-dimethylchroman-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,1-dimethyl-1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-dimethylchroman-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

7-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)quinolin-2(1H)-one;

2-(4-((1,3-dimethyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((3,3-dimethyl-2,3-dihydrobenzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(pyridin-2-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

7-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-2H-benzo[b][1,4]oxazin-3 (4H)-one;

2-(4-(3-fluoro-4-methylphenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

7-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-3,4-dihydroisoquinolin-1-(2H)-one;

3-methyl-6-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)oxazolo[4,5-b]pyridin-2(3H)-one;

tert-butyl-7-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate;

2-methyl-7-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-3,4-dihydroisoquinolin-1(2H)-one;

3-methyl-2-(4-((3-oxo-2,3-dihydrobenzofuran-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(imidazo[1,2-a]pyridin-7-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((6-((1-hydroxypropan-2-yl)oxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((6-((1-hydroxypropan-2-yl)oxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((6-((1-hydroxypropan-2-yl)oxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((6-((1-hydroxypropan-2-yl)oxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1,2,3,4-tetrahydroisoquinolin-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(isoindolin-5-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methyl-1H-benzo[d]imidazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-(4-(1-hydroxyethyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-(4-(1-hydroxyethyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-(hydroxymethyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2-(hydroxymethyl)pyridin-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-(2-hydroxyethyl)-3-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((3-(2-hydroxyethyl)-2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(hydroxymethyl)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5-(hydroxymethyl)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1-(2-hydroxyethyl)-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1-(2-hydroxyethyl)-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

cis-2-(3,3-difluoro-4-phenoxypiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

trans-2-(3,3-difluoro-4-phenoxypiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate;

2-(4-(((1S,2S)-2-fluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(((1R,2R)-2-fluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(((1S,2R)-2-fluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(((1R,2S)-2-fluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(pyridin-3-ylmethoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((2-methylbenzo[d]oxazol-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2-methoxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2-methoxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((2-methyl-3-oxoisoindolin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1H-benzo[d][1,2,3]triazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)-3-fluoropiperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4S)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(3S,4R)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(3S,4R)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)-3-fluoropiperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(3R,4S)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-ethyl-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-ethyl-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-oxido-1,3-dihydrobenzo[c]thiophen-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-methyl-2-(4-((2-oxido-1,3-dihydrobenzo[c]thiophen-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-methyl-2-(4-((2-oxido-1,3-dihydrobenzo[c]thiophen-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(2-amino-2-methylpropoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-ethyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(2-hydroxyethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-phenyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(2-methoxyethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(3,3-difluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(3,3-difluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclobutylmethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(2,2,2-trifluoroethoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(2-(azetidin-1-yl)ethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(4-((5-methylpyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

N-(2-((5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)pyridin-2-yl)oxy)ethyl)acetamide

2-((3R,4R)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclopentylmethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(pyridin-4-ylmethoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclopropylmethoxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((tetrahydrofuran-3-yl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-methylcyclopentyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-(isochroman-6-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-(isochroman-7-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(3,3,3-trifluoro-2-hydroxypropoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-fluorocyclopentyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-methyl-2-(4-(3,3,3-trifluoro-2-hydroxypropoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-methyl-2-(4-(3,3,3-trifluoro-2-hydroxypropoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(neopentyloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(imidazo[1,2-a]pyridin-6-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(oxazol-2-ylmethoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-methylcyclobutyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((1R,5S)-6-((6-methoxypyridin-3-yl)oxy)-3-azabicyclo[3.1.1]heptan-3-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((1R,5S)-6-((6-methoxypyridin-3-yl)oxy)-3-azabicyclo[3.1.1]heptan-3-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-ethylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(bicyclo[1.1.1]pentan-1-ylmethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(3,3,3-trifluoro-2-methylpropoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-(trifluoromethyl)cyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-4-carboxylate;

3-methyl-2-(4-((1-methyl-1H-pyrazol-4-yl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclohexylmethoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(1S,2R)-2-methyl-2-(((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)methyl)cyclopropane-1-carbonitrile;

(1R,2S)-2-methyl-2-(((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)methyl)cyclopropane-1-carbonitrile;

2-(4-isobutoxypiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-methoxycyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(1R,2R)-2-methyl-2-(((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)methyl)cyclopropane-1-carbonitrile;

(1S,2S)-2-methyl-2-(((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)methyl)cyclopropane-1-carbonitrile;

2-(4-((3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-(isochroman-7-yloxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-(methoxymethyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-(4-fluorophenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-methyl-2-(4-((1-methyl-1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-methyl-2-(4-((1-methyl-1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(4-(pyridin-3-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrofuro[2,3-b]pyridin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methyl-2H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(methoxymethyl)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-((2-methoxyethoxy)methyl)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-((2-methoxyethoxy)methyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-(pyridin-2-ylmethoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1H-pyrazolo[3,4-b]pyridin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-dioxido-1,3-dihydrobenzo[c]thiophen-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,2-dimethyl-1H-benzo[d]imidazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,2-dimethyl-1H-benzo[d]imidazol-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl 2-(5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-1H-indazol-1-yl)acetate;

methyl 2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-4-carboxylate;

2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)-3-fluoropiperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-((3S,4R)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(3R,4S)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-((3R,4S)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(3S,4R)-3-fluoro-4-(pyridin-3-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrofuro[3,2-b]pyridin-6-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4S)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-(2-methoxyethoxy)pyridin-3-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3,4-dimethyl-2-(4-((5-methylpyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-cyclopropyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-vinyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carbonitrile;

4-methyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-bromo-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-Ethyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

4-ethyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-3-methyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-Ethyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6,7-diethyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((6-ethoxypyridin-3-yl)oxy)piperidin-1-yl)-7-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((6-ethoxypyridin-3-yl)oxy)piperidin-1-yl)-7-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-(dimethylamino)ethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(6-(2-(dimethylamino)ethyl)-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-phenoxypiperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxypropyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxypropyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(6-(2-hydroxyethyl)-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

6-(2-hydroxyethyl)-3-methyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3,6-dimethyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-((3 S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-phenoxypiperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(6-ethyl-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

6-ethyl-3-methyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-ethyl-2-((3S,4R)-3-fluoro-4-phenoxypiperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-ethyl-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-isopropyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(6-isopropyl-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

6-isopropyl-3-methyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-phenoxypiperidin-1-yl)-6-isopropyl-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(6-cyclopropyl-3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

6-cyclopropyl-3-methyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6-(oxetan-3-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(3-methoxypropyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-methoxyethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-fluorophenoxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-ethoxypyridin-3-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-bis(oxetan-3-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl 2-(3,4-dimethyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)acetate;

2-((3R,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3-ethyl-6-(2-hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6-(pyridin-4-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

methyl 2-(2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)acetate;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(2-methoxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-(4-fluorophenoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(2-methoxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-fluorophenoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-6-(1-hydroxypropan-2-yl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-6-(1-hydroxypropan-2-yl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3-ethyl-6-(2-hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-3,4-dimethyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(4-fluorophenoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)acetic acid

(R)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(1-hydroxypropan-2-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(1-hydroxypropan-2-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-2-((3S,4S)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-6-(2-hydroxyethyl)-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4S)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-6-(2-hydroxyethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclobutylmethoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-6-(2-hydroxyethyl)-2-(4-((2-methoxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-6-(2-hydroxyethyl)-2-(4-((2-methoxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-6-(2-hydroxyethyl)-2-(4-((1-methyl cyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-ethyl-6-(2-hydroxyethyl)-2-(4-((1-methyl-1H-indazol-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-hydroxyethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(1-hydroxypropan-2-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-6-(1-hydroxypropan-2-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3S,4R)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6-(2-hydroxyethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-Cyclopropyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(hydroxymethyl)-3-methyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

7,7-bis(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-phenoxypiperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-((3 S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-((3 S,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((5,7-dihydrofuro[3,4-b]pyridin-3-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-(4-fluorophenoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-((3R,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-(4-fluorophenoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-((3R,4R)-4-((1,3-dihydro-2-benzofuran-5-yl)oxy)-3-fluoropiperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-((3R,4R)-3-fluoro-4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-((3R,4R)-3-fluoro-4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-((3S,4R)-3-fluoro-4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((6-ethoxypyridin-3-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((6-ethoxypyridin-3-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6,7-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6,7-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,7,7-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-7-methylene-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methylisoindolin-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2-acetylisoindolin-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2-acetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6-(pyridin-4-ylmethyl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione;

7-hydroxy-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

tert-butyl-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methylspiro[cyclopropane-1,7-pyrrolo[3,4-b]pyridine-5-(6H)-one;

3-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

4-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-4-(hydroxymethyl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(fluoromethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

4-(fluoromethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carbaldehyde;

3-(difluoromethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

4-(difluoromethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzaldehyde;

2-(4-(3-(hydroxymethyl)phenoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)acetamide

2-(2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)acetamide

2-(4-((2,2-dimethylcyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-cyclopropyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-(hydroxymethyl)cyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-(2-methoxyethyl)-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-hydroxycyclopropyl)methoxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((3-chloro-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((4-chloro-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((3-bromo-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-((1-(3-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)-1H-indazole-3-carbonitrile;

2-(4-((7-fluoro-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6-(3,3,3-trifluoro-2-hydroxypropyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6-(3,3,3-trifluoro-2-hydroxypropyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((6-(methylamino)pyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,2-Dimethyl-2,3-dihydrobenzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-(cyclopropylmethyl)-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((1,2,4,5-tetrahydrobenzo[d]oxepin-7-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

7-(2-hydroxypropan-2-yl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(2-hydroxypropan-2-yl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(2-hydroxypropan-2-yl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-((2-hydroxyethyl)amino)pyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(2-(4-(3-cyanophenoxy)piperidin-1-yl)-3-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)phosphoric acid;

2-(4-((6-hydroxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-chloro-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(cyclobutylmethoxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3,4-dimethyl-2-(4-((1-methyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2-hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2-methoxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2-methoxy-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-((3R,4R)-3-fluoro-4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(3,3-difluoro-4-((1-methyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(3,3-difluoro-4-((1-methyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3,6-dimethyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((1-methyl cyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-ethyl-7-(hydroxymethyl)-6-methyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-((3S,4R)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-ethyl-7-(hydroxymethyl)-6-methyl-2-(4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-((3S,4R)-3-fluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((5-methylpyridin-3-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((5-methylpyridin-3-yl)oxy)piperidin-1l-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-((1-(7-(hydroxymethyl)-3,6-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

(R)-3-((1-(7-(hydroxymethyl)-3,6-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)piperidin-4-yl)oxy)benzonitrile;

(S)-2-(4-(3,4-difluorophenoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-(3,4-difluorophenoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3-ethyl-7-(hydroxymethyl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydroisobenzofuran-5-yl)oxy)piperidin-1-yl)-6-ethyl-7-(hydroxymethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

can-2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3-ethyl-7-(hydroxymethyl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1,3-dihydroisobenzofuran-5-yl)oxy)piperidin-1-yl)-6-ethyl-7-(hydroxymethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-(4-fluorophenoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-(4-fluorophenoxy)piperidin-1-yl)-7-(hydroxymethyl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-7-(hydroxymethyl)-3,6-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((1-methyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((1-methyl-1H-pyrazol-4-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-3,6-dimethyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-ethyl-7-(hydroxymethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-ethyl-7-(hydroxymethyl)-2-(4-(isochroman-7-yloxy)piperidin-1-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-ethyl-7-(hydroxymethyl)-6-methyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-3-ethyl-7-(hydroxymethyl)-6-methyl-2-(4-((1-methyl-1H-indazol-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3-ethyl-7-(hydroxymethyl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((2,3-dihydrobenzofuran-6-yl)oxy)piperidin-1-yl)-3-ethyl-7-(hydroxymethyl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(4-((1,3-dihydroisobenzofuran-5-yl)oxy)piperidin-1-yl)-6-ethyl-7-(hydroxymethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(4-((1,3-dihydroisobenzofuran-5-yl)oxy)piperidin-1-yl)-6-ethyl-7-(hydroxymethyl)-3,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-7-(hydroxymethyl)-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-7-(hydroxymethyl)-2-(4-(isochroman-6-yloxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-4-vinyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-methyl-2-(4-((2-oxo-2,3-dihydro-1H-inden-5-yl)oxy)piperidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(3,3-difluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-2-(3,3-difluoro-4-((1-methylcyclopropyl)methoxy)piperidin-1-yl)-3-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one; and

6-(2-hydroxyethyl)-7-(hydroxymethyl)-2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

or a pharmaceutically acceptable salt thereof.

11. A pharmaceutical composition which comprises an inert carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

12. A method for the treatment of a neurological and/or psychiatric disorder characterized by muscarinic acetylcholine receptor dysfunction comprising the step of administering at least one compound of claim 1 , or a pharmaceutically acceptable salt of said compound, to a mammalian patient in need thereof in an amount effective for the treatment of said disorder.

13. The method of claim 12 , wherein the patient has been diagnosed with a need for treatment of the disorder prior to the administering step.

14. The method of claim 12 , wherein the disorder is a neurological and/or psychiatric disorder characterized by mAChR M4 dysfunction.

15. The method of claim 12 , wherein the disorder is a psychotic disorder.

16. The method of claim 15 , wherein the psychotic disorder is selected from schizophrenia, brief psychotic disorder, schizophreniform disorder, schizoaffective disorder, delusional disorder, shared psychotic disorder, catastrophic schizophrenia, postpartum psychosis, psychotic depression, psychotic break, tardive psychosis, myxedematous psychosis, occupational psychosis, menstrual psychosis, secondary psychotic disorder, bipolar I disorder with psychotic features, and substance-induced psychotic disorder.

17. The method of claim 12 , wherein the disorder is a cognitive disorder.

18. The method of claim 17 , wherein the cognitive disorder is selected from amnesia, dementia, delirium, amnestic disorder, substance-induced persisting delirium, dementia due to HIV disease, dementia due to Huntington's disease, dementia due to Parkinson's disease, Parkinsonian-ALS demential complex, dementia of the Alzheimer's type, age-related cognitive decline, and mild cognitive impairment.

19. A method for the treatment of a disorder selected from schizophrenia, brief psychotic disorder, schizophreniform disorder, schizoaffective disorder, delusional disorder, shared psychotic disorder, catastrophic schizophrenia, positive and negative symptoms of schizophrenia, secondary psychotic disorder, bipolar I disorder with psychotic features, and substance-induced psychotic disorder, in a human patient comprising administering a compound of claim 1 , or a pharmaceutically acceptable salt of said compound, to the patient in need thereof in an amount effective for the treatment of said disorder.

20. A method for the treatment of a disorder selected from amnesia, dementia, delirium, amnestic disorder, dementia of the Alzheimer's type, dementia associated with Alzheimer's disease, age-related cognitive decline, and mild cognitive impairment, in a human patient comprising administering a compound of claim 1 , or a pharmaceutically acceptable salt of said compound, to the patient in need thereof in an amount effective for the treatment of said disorder.