IP Library Granted Patent US 10,166,248
Granted Patent B1
US 10,166,248 · App. 15/387,507 · Granted Jan 1, 2019

Methods of preventing platelet activation

Inventors: John A. Oates (Nashville, TN); Olivier Boutaud (Nashville, TN); Irene Zagol-Ikapitte (Nashville, TN)
Assignee: Vanderbilt University
A61K31/609A01N1/0226A61P7/00A61P7/02A61P7/06
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Quick Facts
Patent No.
US 10,166,248
App. No.
15/387,507
Granted
Jan 1, 2019
Kind
B1
Abstract

A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one γ-KA scavenger compound, or a pharmaceutically acceptable salt thereof.

Claims (8)

1. A method of reducing the occurrence of malondiadehyde protein modification in a subject in need thereof, comprising:

identifying a subject with increased platelet activation;

administering to said subject a malondiadehyde adduct formation reducing amount of a compound of the following formula:

or a pharmaceutically acceptable salt thereof;

to thereby reduce said protein modification.

2. The method of claim 1 , wherein the compound is

3. The method of claim 1 , wherein the compound is selected from the following formula:

or a pharmaceutically acceptable salt thereof.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 21, 2018
From: VANDERBILT UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 045299/0268 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2017
From: OATES, JOHN A; BOUTAUD, OLIVIER; ZAGOL-IKAPITTE, IRENE
To: VANDERBILT UNIVERSITY
Reel/Frame 041282/0083 →
Continuity (1)
Provisional Application 62270435 · Dec 21, 2015