IP Library › Granted Patent US 10,040,822
Granted Patent B2
US 10,040,822 · App. 15/393,720 · Granted Aug 7, 2018

Neuroprotective composition and method of use

Inventors: Dennis J. Goebel (Wixom, MI); John Marshall (Barrington, RI)
Assignee: National Institutes of Health, U.S. Dept. of Health and Human Services, NIH Division of Extramural Inventions and Technology Resources
C07K7/06A61K9/0019A61K38/08A61K38/00
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Quick Facts
Patent No.
US 10,040,822
App. No.
15/393,720
Granted
Aug 7, 2018
Kind
B2
Abstract

A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines (SEQ ID NO: 1), and further comprising 1 or more terminal cysteines. The composition is administered in therapeutically effective dosages prophylactically or as soon as possible post-injury in treating neuronal injury.

Claims (6)

1. A therapeutic method of treating ischemic neuronal injury comprising administering a therapeutically effective dosage form of a polyarginine peptide consisting of from 5 to 9 arginines and 1 or more terminal cysteines.

2. The method of claim 1 wherein said polyarginine peptide is C-s-s-CRRRRRRR (SEQ ID NO: 8).

3. The method of claim 2 wherein administration is i.v.

4. The method of claim 3 wherein administration is from about 0.01 mg/kg to about 20 mg/kg.

5. The therapeutic method of claim 1 wherein said therapeutically effective dosage form of a polyarginine peptide consists of 9 arginines.

6. The therapeutic method of claim 1 wherein said therapeutically effective dosage form is oral dosage form or injectable solution.

Assignments (1)
CONFIRMATORY LICENSE Recorded Feb 2, 2017
From: BROWN UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041591/0041 →
Continuity (2)
Continuation 14391293
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