Therapeutic compounds
The invention provides compounds of formulae I, II, III, and IV: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.
1. A method for inhibiting cancer cell growth comprising contacting the cell in vitro or in vivo with an effective amount of a compound of formula II:
or a salt thereof wherein:
R 1 is H, or (C 1 -C 6 )alkyl, wherein each (C 1 -C 6 )alkyl, that is optionally substituted with one or more groups independently selected from halo;
the bond represented by --- is a single bond or a double bond;
D is
R 2 is COOH; and R 3 and R 4 are each H;
wherein the cancer is colon cancer.
2. The method of claim 1 , wherein the bond represented by --- is a single bond.
3. The method of claim 1 , wherein the bond represented by --- is a double bond.
4. The method of claim 1 , wherein D is
5. The method of claim 1 , wherein D is
6. A method for inhibiting cancer cell growth comprising contacting the cell in vitro or in vivo with an effective amount of the compound:
or a pharmaceutically acceptable salt thereof, wherein the cancer is colon cancer.
7. A method for inhibiting cancer cell growth comprising contacting the cell in vitro or in vivo with an effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof; wherein the cancer is colon cancer.
8. A method for inhibiting cancer cell growth comprising contacting the cell in vitro or in vivo with an effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof; wherein the cancer is colon cancer.