Iminosugars and methods of treating viral diseases
Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
1. A method of treating a Dengue viral infection comprising administering to a human subject in need thereof an effective amount of a compound of formula:
wherein:
W 1-4 are independently selected from hydrogen and alkyl groups; and
R is an alkyl group or an oxaalkyl group.
2. The method of claim 1 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen and R is a C 1-16 alkyl group.
3. The method of claim 2 , wherein R is a C 4-12 alkyl group.
4. The method of claim 3 , wherein R is an unsubstituted C 4-12 alkyl group.
5. The method of claim 3 , wherein R is an unsubstituted C 8-10 alkyl group.
6. The method of claim 1 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen and R is an C 1-16 oxaalkyl group containing from 1 to 3 oxygen atoms.
7. The method of claim 6 , wherein R is an C 4-12 oxaalkyl group containing from 1 to 2 oxygen atoms.
8. The method of claim 7 , wherein R is an unsubstituted C 4-12 oxaalkyl group.
9. The method of claim 7 , wherein R is an unsubstituted C 8-10 oxaalkyl group.
10. The method of claim 1 , wherein the Dengue viral infection is caused by a Dengue 2 virus.
11. A method of treating a Dengue viral infection comprising administering to a human subject in need thereof an effective amount of a compound of formula:
wherein:
W 1-4 are independently selected from hydrogen and alkyl groups; and
R is
wherein:
R 1 is an alkyl group;
X 1-5 are independently selected from H, NO 2 , N 3 , or NH 2 ;
Y is absent or is a C 1 -alkyl group, other than carbonyl; and
Z is selected from a bond or NH; provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a C 1 -alkyl group, other than carbonyl.
12. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen and Z is NH.
13. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen, Z is a bond, and Y is absent.
14. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen, Z is NH, and R 1 -Y is a C 4-12 alkyl group.
15. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen and R 1 is an unsubstituted alkyl group.
16. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen and each of X 2 , X 4 , and X 5 is hydrogen.
17. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen and R 1 -Y is a C 4-12 alkyl group.
18. The method of claim 17 , wherein R 1 -Y is an unsubstituted C 4 - 12 alkyl group.
19. The method of claim 16 , wherein X 1 is NO 2 and X 3 is N 3.
20. The method of claim 11 , wherein each of W 1 , W 2 , W 3 , and W 4 is hydrogen, Z is NH, R 1 -Y is an unsubstituted C 4 - 10 alkyl group, X 1 is NO 2 , and X 3 is N 3.
21. The method of claim 11 , wherein the Dengue viral infection is caused by a Dengue 2 virus.