Pharmaceutical use of FAM19A5 involved in regulating gliogenesis
The present invention relates to the pharmaceutical use of FAM19A5 involved in regulating gliogenesis, and more specifically, to the use of FAM19A5 in the prevention, diagnosis, or treatment of central nervous system injuries, degenerative brain diseases, or central nervous system diseases, FAM19A5 being spread in the neural stem cells in vertebrates and regulating gliogenesis.
1. A method of determining the expression level of FAM19A5 in a subject having a central nervous system damage, degenerative brain disease, or central nervous system disease, comprising:
detecting whether the expression level of FAM19A5 from a biological sample obtained from the subject is increased compared to the expression level of FAM19A5 from a normal control by contacting the sample with an antibody or a fragment thereof that specifically binds to FAM19A5 and measuring the expression level of FAM19A5.
2. The method of claim 1 , wherein the expression level of FAM19A5 is 3 fold or higher.
3. The method of claim 1 , wherein the expression level of FAM19A5 is 7 fold or higher.
4. The method of claim 1 , wherein the biological sample is tissue, cells, blood, serum, plasma, saliva, or urine.
5. The method of claim 1 , wherein the central nervous system damage, degenerative brain disease, or central nervous system disease is associated with an onset of reactive astrocytes.
6. The method of claim 5 , further comprising administering an antibody or a fragment thereof that specifically binds to FAM19A5.
7. The method of claim 1 , wherein the central nervous system damage, degenerative brain disease, or central nervous system disease is associated with an increase of the number of oligodendrocyte progenitor cells expressing neuron-glial antigen 2 (NG2) in an early stage of neuronal injury.
8. The method of claim 1 , wherein the central nervous system damage, degenerative brain disease, or central nervous system disease is a traumatic brain injury, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, or brain tumor.
9. The method of claim 8 , further comprising administering an antibody or a fragment thereof that specifically binds to FAM19A5.
10. The method of claim 1 , wherein the central nervous system damage, degenerative brain disease, or central nervous system disease is ALS.
11. The method of claim 1 , wherein the central nervous system damage, degenerative brain disease, or central nervous system disease is a traumatic brain injury.
12. The method of claim 1 , wherein the antibody is a monoclonal antibody.
13. The method of claim 1 , wherein the antibody is a polyclonal antibody.
14. The method of claim 1 , wherein the antibody is a human antibody or a humanized antibody.
15. The method of claim 1 , wherein the antibody is a diabody or linear antibody.
16. The method of claim 1 , wherein the antibody fragment is a Fab, Fab′, F(ab′)2, Fv fragment, or single chain antibody molecule.
17. The method of claim 1 , further comprising administering an antibody or a fragment thereof that specifically binds to FAM19A5.
18. The method of claim 17 , wherein the antibody or a fragment thereof that specifically binds to FAM19A5 is a monoclonal antibody.