IP Library › Granted Patent US 10,058,535
Granted Patent B2
US 10,058,535 · App. 15/413,889 · Granted Aug 28, 2018

Nuclear transport modulators and uses thereof

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Quick Facts
Patent No.
US 10,058,535
App. No.
15/413,889
Granted
Aug 28, 2018
Kind
B2
Abstract

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using the compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

Claims (2)

1. A method of treating amyotrophic lateral sclerosis in a subject in need thereof, comprising orally administering to the subject a therapeutically effective amount of a compound represented by the following structural formula:

or a pharmaceutically acceptable salt thereof.

Assignments (5)
PATENT SECURITY AGREEMENT Recorded Oct 10, 2025
From: KARYOPHARM THERAPEUTICS INC.
To: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS COLLATERAL TRUSTEE
Reel/Frame 073058/0504 →
PATENT SECURITY AGREEMENT Recorded Oct 10, 2025
From: KARYOPHARM THERAPEUTICS INC.
To: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS AGENT
Reel/Frame 073058/0647 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2024
From: BIOGEN MA INC.
To: KARYOPHARM THERAPEUTICS INC.
Reel/Frame 067779/0216 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2018
From: SANDANAYAKA, VINCENT P.; SHECHTER, SHARON; SHACHAM, SHARON; MCCAULEY, DILARA; BALOGLU, ERKAN
To: KARYOPHARM THERAPEUTICS INC.
Reel/Frame 046283/0934 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 6, 2018
From: KARYOPHARM THERAPEUTICS INC.
To: BIOGEN MA INC.
Reel/Frame 045120/0273 →