Devices and methods for reducing intrathoracic pressure

1. A method for reducing a renal pressure in a subject, comprising:

sensing a physiologic parameter relating to cardiac function of a subject undergoing intrinsic respiration via one or multiple sensors positioned internally or externally within the patient;

determining one or more hemodynamic parameters of the subject based on the physiologic parameter;

determining a mean or average intrathoracic pressure based on the physiologic parameter; and

stimulating a phrenic nerve or diaphragm of the subject at least during a portion of an exhalation and/or rest cycle to maintain the diaphragm contracted relative to a non-stimulated diaphragm during the exhalation and/or rest cycle over a sustained period of time via an electrode to increase a functional residual capacity of the subject such that the mean or average intrathoracic pressure is decreased and the renal pressure is correspondingly reduced to improve the one or more hemodynamic parameters.

2. The method of claim 1 wherein the sensing of the physiologic parameter comprises monitoring a cardiac output of the patient.

3. The method of claim 2 wherein the monitoring of the cardiac output comprises monitoring one or more of a pulmonary artery, right ventricle, left atrium, left ventricle pressures, cardiac contractility, and/or cardiac and intrathoracic impedances.

4. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises adjusting a stimulation applied to the phrenic nerve or diaphragm in response to the physiologic parameter such that an initial pressure within a thoracic chamber is reduced.

5. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises stimulating to improve a hemodynamic parameter of the heart.

6. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises adjusting a stimulation applied to the phrenic nerve or diaphragm in response to the physiologic parameter to improve a cardiac output.

7. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises stimulating in an acute or chronic setting.

8. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises decreasing a right atrial pressure and improving kidney filtration.

9. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises reducing a cardiac filling pressure to reduce the renal pressure.

10. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises modulating or manipulating the intrathoracic pressure to activate renal sympathetic activity.

11. The method of claim 1 wherein the stimulating of the phrenic nerve or diaphragm comprises modulating or manipulating the intrathoracic pressure to activate renal sympathetic activity such that a kidney glomerular filtration rate (GFR) is increased.

12. The method of claim 1 wherein stimulating the phrenic nerve or diaphragm comprises reducing a sympathetic efferent outflow to a heart of the patient such that norepinephrine spillover is reduced.

13. A device for reducing a renal pressure in a patient, comprising:

at least one electrode in electrical communication with a diaphragm or phrenic nerve tissue of a patient's body, wherein the at least one electrode or a second electrode is configured for sensing a physiologic parameter relating to the patient's hemodynamics; and,

a control unit in electrical communication with the at least one electrode,

wherein the control unit is programmed to generate an electrical stimulation signal in response to a sensed hemodynamic parameter and deliver the electrical stimulation signal through the at least one electrode at least during a portion of an exhalation and/or rest cycle to maintain the diaphragm contracted relative to a non-stimulated diaphragm during the exhalation and/or rest cycle over a sustained period of time to the diaphragm or phrenic nerve tissue to increase a functional residual capacity of the patient undergoing intrinsic respiration,

wherein the control unit is further programmed to deliver the electrical stimulation signal until a mean or average intrathoracic pressure as determined by the control unit and based upon the physiologic parameter is decreased and a renal pressure is correspondingly reduced.

14. The device of claim 13 wherein the control unit is programmed to sense a cardiac related parameter of the patient.

15. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to cause a titratable diaphragm contraction such that an initial pressure within a thoracic chamber is reduced.

16. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to improve a hemodynamic parameter of the heart.

17. The device of claim 13 wherein the control unit is programmed to adjust the electrical stimulation signal in response to the physiologic parameter to improve a cardiac output.

18. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to decrease a right atrial pressure and improve kidney filtration.

19. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to reduce a cardiac filling pressure to reduce the renal pressure.

20. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to modulate or manipulate the intrathoracic pressure to activate renal sympathetic activity.

21. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to modulate or manipulate the intrathoracic pressure to activate renal sympathetic activity such that a kidney glomerular filtration rate (GFR) is increased.

22. The device of claim 13 wherein the control unit is programmed to deliver the electrical stimulation signal to reduce a sympathetic efferent outflow to a heart of the patient such that norepinephrine spillover is reduced.