Moisturizing compositions and uses thereof
Embodiments herein are directed to moisturizing compositions comprising interpenetrating polymer networks, methods of making moisturizing compositions and methods of using moisturizing compositions.
1. An interpenetrating polymer network moisturizing topical composition comprising:
about 0.01% w/w to about 5% w/w of crosslinked gellan gum;
about 0.01% w/w to about 5% w/w of cetyl hydroxyethylcellulose;
about 0.01% w/w to about 5% w/w of sodium hyaluronate;
about 0.01% w/w to about 5% w/w of a mono-, or di-valent ion; and
about 25% w/w to about 80% w/w of a humectant selected from glycerin, diglycerin, and a combination thereof;
wherein the cetyl hydroxyethylcellulose and the sodium hyaluronate are interlaced; and
wherein the crosslinked gellan gum is crosslinked via ionic bonds, through the mono-, or di-valent ion, and entraps the interlaced cetyl hydroxyethylcellulose, the sodium hyaluronate, and the humectant to form the interpenetrating polymer network moisturizing topical composition.
2. The moisturizing topical composition of claim 1 , wherein the mono-, or di-valent ion is selected from the group consisting of 2-Pyrrolidone-5-Carboxylic Acid (PCA), calcium PCA, sodium PCA, zinc PCA, magnesium PCA, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof.
3. The moisturizing topical composition of claim 1 , wherein the moisturizing composition is selected from the group consisting of liquid, solution, emulsion, suspension, triturate, jelly, foam, paste, ointment, shampoo, adhesive, cream, serum, milk, lotion, salve, oil, butter, gel, and balm.
4. A method of treating dry and/or irritated skin comprising administering an interpenetrating polymer network moisturizing topical composition comprising:
about 0.01% w/w to about 5% w/w of crosslinked gellan gum;
about 0.01% w/w to about 5% w/w of cetyl hydroxyethylcellulose;
about 0.01% w/w to about 5% w/w of sodium hyaluronate;
about 0.01% w/w to about 5% w/w of a mono-, or di-valent ion; and
about 25% w/w to about 80% w/w of a humectant selected from glycerin, diglycerin, and a combination thereof;
wherein the cetyl hydroxyethylcellulose and the sodium hyaluronate are interlaced; and
wherein the crosslinked gellan gum is crosslinked via ionic bonds, through the mono-, or di-valent ion, and entraps the interlaced cetyl hydroxyethylcellulose, the sodium hyaluronate, and the humectant to form the interpenetrating polymer network moisturizing topical composition.
5. The method of claim 4 , wherein the mono-, or di-valent ion is selected from the group consisting of 2-Pyrrolidone-5-Carboxylic Acid (PCA), calcium PCA, sodium PCA, zinc PCA, magnesium PCA, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof.
6. The method of claim 4 , wherein the moisturizing composition is a formulation selected from the group consisting of liquid, solution, emulsion, suspension, triturate, jelly, foam, paste, ointment shampoo, adhesive, cream, serum, milk, lotion, salve, oil, butter, gel, and balm.
7. A method of producing a interpenetrating polymer network moisturizing topical composition, the method comprising:
dispersing a non-crosslinked gellan gum capable of crosslinking in water to form a first phase;
combining sodium hyaluronate and cetyl hydroxyethylcellulose with a humectant selected from glycerin, diglycerin, and a combination thereof to form a second phase;
combining the first and second phases to form a third phase of uncrosslinked interlaced gellan gum, sodium hyaluronate, and cetyl hydroxyethylcellulose;
adding a mono-valent, di-valent ion or a combination thereof to the third phase to crosslink the gellan gum to form the interpenetrating polymer network moisturizing topical composition,
wherein the interpenetrating polymer network moisturizing topical composition is made up of a crosslinked gellan gum in a three dimensional structure, sodium hyaluronate, cetyl hydroxyethylcellulose, and the humectant; wherein the crosslinked gellan gum entraps the interlaced sodium hyaluronate, cetyl hydroxyethylcellulose, and the humectant, and
wherein the crosslinked gellan gum is crosslinked via ionic bonds wherein the composition comprises
about 0.01% w/w to about 5% w/w of crosslinked gellan gum;
about 0.01% w/w to about 5% w/w of cetyl hydroxyethylcellulose;
about 0.01% w/w to about 5% w/w of sodium hyaluronate;
about 0.01% w/w to about 5% w/w of the mono-, or di-valent ion; and
about 25% w/w to about 80% w/w of the humectant.
8. The method of claim 7 , the mono-valent, di-valent ion is selected from group consisting of 2-Pyrrolidone-5-Carboxylic Acid (PCA), calcium PCA, sodium PCA, zinc PCA, magnesium PCA, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof.
9. A drug or active ingredient delivery system comprising:
about 0.01% w/w to about 5% w/w of crosslinked gellan gum;
about 0.01% w/w to about 5% w/w of cetyl hydroxyethylcellulose;
about 0.01% w/w to about 5% w/w of sodium hyaluronate;
about 0.01% w/w to about 5% w/w of a mono-, or di-valent ion;
about 25% w/w to about 80% w/w of a humectant selected from glycerin, diglycerin, and a combination thereof; and
a drug or active ingredient;
wherein the cetyl hydroxyethylcellulose and the sodium hyaluronate are interlaced; and
wherein the crosslinked gellan gum is crosslinked via ionic bonds, through the mono-, or di-valent ion, and entraps the cetyl hydroxyethylcellulose, the sodium hyaluronate, the humectant, and the drug or active ingredient to form the interpenetrating polymer network moisturizing topical composition.
10. The drug or active ingredient delivery system of claim 9 , wherein the mono-, or di-valent ion is selected from the group consisting of 2-Pyrrolidone-5-Carboxylic Acid (PCA), calcium PCA, sodium PCA, zinc PCA, magnesium PCA, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof.
11. The drug or active ingredient delivery system of claim 9 , wherein the drug or active ingredient is selected from the group consisting of benzoyl peroxide, salicylic acid, willowbark extract, poly hydroxyacid, tannic acid, hydroxybenzoic acid, juniperic acid, tartaric acid, glycolic acid, lactic acid, citric acid, retinol, antioxidants, vitamin A, retinoid, tretinoin, tazarotene, ibuprofen, diclofenac, felbinac, ketoprofen, piroxicam and any combination thereof.
12. The moisturizing topical composition of claim 1 , wherein the mono-, or di-valent ion is selected from calcium PCA, magnesium PCA, and combinations thereof.
13. The moisturizing topical composition of claim 1 , wherein the humectant is in an amount of about 30%.
14. The moisturizing topical composition of claim 1 , wherein the humectant is glycerin and is in an amount of about 30%.
15. The moisturizing topical composition of claim 1 , wherein the viscosity of the moisturizing topical composition is about 400 to about 1400 cps.
16. The moisturizing topical composition of claim 1 , wherein the gellan gum is in an amount of about 0.11% w/w, the cetyl hydroxyethylcellulose is in an amount of about 0.30% w/w, the sodium hyaluronate is in an amount of about 0.12% w/w, the mono-, or di-valent ion is a combination of magensium PCA in an amount of about 0.30% w/w and calcium PCA in an amount of about 0.30% w/w, and the humectant is glycerin in an amount of about 30% w/w.