IP Library › Granted Patent US 11,020,386
Granted Patent B2
US 11,020,386 · App. 15/431,624 · Granted Jun 1, 2021

Methods and compositions for preventing opioid abuse

Inventors: Matthew Surman (Albany, NY); Kathryn Golden (Clifton Park, NY); Paolo Pasetto (Guilderland, NY); Xiaomin Jin (Slingerland, NY); Xiaowu Jiang (East Greenbush, NY); Fatoumata Camara (Albany, NY); John K. Thottathil (Ivanhoe, IL)
Assignees: ALBANY MOLECULAR RESEARCH, INC.; 3ST RESEARCH LLC
A61K31/485A61K47/542C07D489/08
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,020,386
App. No.
15/431,624
Granted
Jun 1, 2021
Kind
B2
Abstract

Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.

Claims (45)

1. An opioid prodrug having the structure

wherein,

Z is —H or

R 1 is —H;

R 2 is —H or —OR 6 ;

R 3 is H, or —OR 7 ;

R 4 is alkyl, aryl, or —CH 2 COOH;

R 5 is selected from the group consisting of —OH,

R 6 is —H or —C(O)CH 3 ; and

R 7 is selected from the group consisting of —H, —C(O)CH 3 ,

with the proviso that when Z is —H, then R 3 is not —H, or —OH.

2. The opioid prodrug of claim 1 , wherein R 2 is —H.

3. The opioid prodrug of claim 1 , wherein R 2 is —OR 6 .

4. The opioid prodrug of claim 3 , wherein R 6 is —H.

5. The opioid prodrug of claim 1 , wherein R 3 is —H.

6. The opioid prodrug of claim 1 , wherein R 3 is —OR 7 .

7. The opioid prodrug of claim 6 , wherein R 7 is —H.

8. The opioid prodrug of claim 6 , wherein R 7 is selected from the group consisting of —C(O)CH 3 ,

9. The opioid prodrug of claim 1 , wherein R 4 is —CH 2 COOH.

10. The opioid prodrug of claim 1 , wherein R 5 is —OH.

11. The opioid prodrug of claim 1 , wherein R 5 is

12. The opioid prodrug of claim 1 selected from the group consisting of

13. A pharmaceutical composition, comprising:

the opioid prodrug of claim 1 ; and

at least one pharmaceutical additive.

14. The opioid prodrug of claim 13 having the formula:

15. The opioid prodrug of claim 13 having the formula:

16. The opioid prodrug of claim 13 having the formula:

17. The opioid prodrug of claim 13 having the formula:

18. The opioid prodrug of claim 13 having the formula:

19. The opioid prodrug of claim 13 having the formula:

20. The opioid prodrug of claim 13 having the formula:

21. The opioid prodrug of claim 13 having the formula:

22. The opioid prodrug of claim 13 having the formula:

23. The opioid prodrug of claim 13 having the formula:

24. The opioid prodrug of claim 13 having the formula:

25. The opioid prodrug of claim 13 having the formula:

26. The opioid prodrug of claim 13 having the formula:

27. The opioid prodrug of claim 13 having the formula:

28. The opioid prodrug of claim 13 having the formula:

29. The opioid prodrug of claim 13 having the formula:

30. The opioid prodrug of claim 13 having the formula:

31. The opioid prodrug of claim 13 having the formula:

32. The opioid prodrug of claim 13 having the formula:

33. The opioid prodrug of claim 13 having the formula:

Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 3, 2025
From: CURIA GLOBAL, INC.
To: CURIA BUFFALO R&D, LLC
Reel/Frame 073096/0462 →
CHANGE OF NAME Recorded May 20, 2025
From: ALBANY MOLECULAR RESEARCH, INC.
To: CURIA GLOBAL, INC.
Reel/Frame 071298/0097 →
ASSIGNMENT OF SECURITY INTEREST IN INTELLECTUAL PROPERTY, RECORDED ON SEPTEMBER 1, 2017, AT REEL/FRAME 043746/0621 Recorded Mar 17, 2025
From: BARCLAYS BANK PLC, AS EXISTING AGENT
To: APOLLO ADMINISTRATIVE AGENCY LLC, AS SUCCESSOR AGENT
Reel/Frame 070531/0279 →
SECURITY INTEREST Recorded Sep 6, 2021
From: CURIA GLOBAL, INC. (FKA ALBANY MOLECULAR RESEARCH, INC.); CURIA MASSACHUSETTS, INC. (FKA AMRI BURLINGTON, INC.); CURIA WISCONSIN, INC. (FKA CEDARBURG PHARMACEUTICALS, INC.); CURIA INDIANA, LLC (FKA AMRI SSCI, LLC); CURIA NEW MEXICO, LLC (FKA OSO BIOPHARMACEUTICALS MANUFACTURING, LLC); CURIA IP HOLDINGS, LLC
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 057423/0665 →
RELEASE OF SECURITY INTEREST Recorded Oct 29, 2020
From: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
To: ALBANY MOLECULAR RESEARCH, INC.; AMRI BURLINGTON, INC.; CEDARBURG PHARMACEUTICALS, INC.; EUTICALS INC.; OSO BIOPHARMACEUTICALS MANUFACTURING, LLC
Reel/Frame 054252/0687 →
FIRST LIEN SECURITY AGREEMENT Recorded Sep 1, 2017
From: ALBANY MOLECULAR RESEARCH, INC.; AMRI BURLINGTON, INC.; CEDARBURG PHARMACEUTICALS, INC.; EUTICALS INC.; OSO BIOPHARMACEUTICALS MANUFACTURING, LLC-BY ITS SOLE MEMBER: ALO ACQUISITION LLC
To: BARCLAYS BANK, PLC AS COLLATERAL AGENT
Reel/Frame 043746/0621 →
SECOND LIEN SECURITY AGREEMENT Recorded Sep 1, 2017
From: ALBANY MOLECULAR RESEARCH, INC.; AMRI BURLINGTON, INC.; CEDARBURG PHARMACEUTICALS, INC.; EUTICALS INC.; OSO BIOPHARMACEUTICALS MANUFACTURING LLC-BY ITS SOLE MEMBER:ALO ACQUISITION LLC
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 043746/0657 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2017
From: THOTTATHIL, JOHN K.
To: 3ST RESEARCH LLC
Reel/Frame 042970/0273 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 17, 2017
From: SURMAN, MATTHEW; GOLDEN, KATHRYN; PASETTO, PAOLO; JIN, XIAOMIN; JIANG, XIAOWU; CAMARA, FATOUMATA
To: ALBANY MOLECULAR RESEARCH, INC.
Reel/Frame 041749/0642 →
Continuity (3)
Continuation 15139836 · Apr 27, 2016
Provisional Application 62153157 · Apr 27, 2015
Related Publication 20170151232A1 · Jun 1, 2017