Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
Compositions and methods comprising at least one biguanide compound and at least one statin combined with at least one additional active agent in fixed dose combinations are provided for reducing cardiometabolic risk, and for the treatment of cardiovascular disease, wherein the biguanide compound is formulated for delayed release.
1. A method of reducing cardiometabolic risk in a patient in need thereof, comprising administering a combination dosage form comprising at least one biguanide compound, at least one statin and at least one additional active agent, wherein said at least one biguanide compound is formulated for delayed release and has reduced average systemic bioavailability as compared to an immediate-release formulation having an equivalent amount of said biguanide compound.
2. The method according to claim 1 , wherein reducing cardiometabolic risk comprises treating an underlying metabolic disorder in said patient.
3. The method according to claim 1 , wherein reducing cardiometabolic risk comprises treating cardiovascular disease in said patient.
4. The method according to claim 1 , wherein said combination dosage form is administered to said patient once daily.
5. The method according to claim 4 , wherein said combination dosage form is administered to said patient once daily in the morning.
6. The method according to claim 1 , wherein said at least one additional active agent is selected from the group consisting of anti-hypertensives, anti-platelet agents, diuretics, bile acid sequesterants, incretin mimetics and enhancers, anti-obesity agents, oral anti-diabetic agents, and anti-atherosclerotics.
7. The method according to claim 6 , wherein the combination dosage form comprises at least two, three, or four additional active agents.
8. The method according to claim 1 , wherein the combination dosage form comprises less than 1000, 950, 900 or 850 mg of metformin or other biguanide.
9. The method according to claim 1 , wherein the combination dosage form comprises from about 300 mg to about 900 mg of metformin.
10. The method according to claim 1 , wherein the combination dosage form comprises from about 400 mg to about 800 mg of metformin.
11. The method according to claim 6 , wherein said oral anti-diabetic agent is selected from the group consisting of sulfonylureas, nonsulfonylureas, thiazolidinediones, dual PPAR agonists, dipeptidyl peptidase-4 inhibitors, SGLT1 or SGLT2 inhibitors, meglitinides, alpha-glucosidase inhibitors, agonists of GPR40, GPR120, GPR119, GPR41, and GPR43.
12. The method according to claim 6 , wherein said antihypertensive is selected from the group consisting of beta blockers, alpha blockers, mixed alpha/beta blockers, calcium channel blockers such as dihydropyridines and non-dihydropyridines, renin inhibitors, ACE inhibitors, and angiotensin II receptor antagonists.
13. The method according to claim 6 , wherein said anti-platelet medication is selected from the group consisting of cyclooxygenase inhibitors, ADP receptor inhibitors, phosphodiesterase inhibitors, adenose reuptake inhibitors, thromboxane synthase or receptor inhibitors, anagrelide, prasugrel, and cloricromen.
14. The method according to claim 6 , wherein said diuretic is selected from the group consisting of loop diuretics, thiazide diuretics, thiazide-like diuretics, and potassium-sparing diuretics.
15. The method according to claim 1 , wherein the at least one biguanide compound is targeted for delivery to the small intestine, and the dosage form is enterically coated to release said biguanide compound at a pH at or above 5.0 or 5.5.
16. The method according to claim 1 , wherein the at least one biguanide compound is targeted for delivery to the distal small intestine, and the dosage form is enterically coated to release said biguanide compound at a pH at or above 6.0, 6.5 or 7.0.
17. The method according to claim 1 , wherein said combination dosage form comprises metformin, at least one statin, at least one anti-hypertensive and optionally at least one anti-platelet medication.
18. The method according to claim 17 , wherein said anti-hypertensive comprises an ACE inhibitor or an angiotensin II receptor antagonist.
19. The method according to claim 1 , wherein said combination dosage form comprises from about 600-800 mg of metformin, from about 20-40 mg of simvastatin or atorvastatin, from about 20-25 mg of benazepril, lisinopril or losartan, and from about 75-90 mg of aspirin.
20. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 10% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
21. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 15% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
22. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 20% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
23. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 25% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
24. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 30% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
25. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 35% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
26. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 40% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
27. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 45% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
28. The method according to claim 1 , wherein said reduced average systemic bioavailability is more than a 50% reduction in average systemic bioavailability in comparison with an immediate-release formulation having an equivalent amount of metformin.
29. The method according to claim 16 , wherein the dosage form is enterically coated to release said biguanide compound at a pH at or above 6.5.