IP Library Granted Patent US 10,799,869
Granted Patent B2
US 10,799,869 · App. 15/440,706 · Granted Oct 13, 2020

Fluid transport apparatus, flexible conduit, method of manufacturing flexible conduit, and storage method

Inventor: Michael A. Zumbrum (New Oxford, PA)
Assignee: Sartorius Stedim North America Inc.
B01L3/561A01N1/0268A61M39/00A61M39/08B01L2300/123B01L2300/1894
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Quick Facts
Patent No.
US 10,799,869
App. No.
15/440,706
Granted
Oct 13, 2020
Kind
B2
Abstract

A fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough is provided. The fluid transport apparatus may include a conduit extending between a first terminus and a second terminus. The conduit may include platinum catalyzed silicone rubber having methyl and phenyl side groups. The conduit may have a storage modulus of 10 8 or less Pascals at −75 degrees Celsius. At least one fitting may be connected to the first terminus. A fluid storage accessory may be engaged with the second terminus. A related flexible conduit, method of manufacturing a flexible conduit, and storage method are also provided.

Claims (32)

1. A fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough, the fluid transport apparatus comprising:

a conduit having a first terminus and a second terminus, the conduit extending between the first terminus and the second terminus, the conduit formed of platinum catalyzed silicone rubber having methyl and phenyl side groups, the conduit having a storage modulus of 10 8 or less Pascals at −75 degrees Celsius;

at least one fitting connected to the first terminus; and

a fluid storage accessory engaged with the second terminus.

2. The fluid transport apparatus of claim 1 , wherein the platinum catalyzed silicone rubber having methyl and phenyl side groups has less than 0.5 weight percent extractables.

3. The fluid transport apparatus of claim 1 , wherein the conduit has a storage modulus of 10 8 or less Pascals at −100 degrees Celsius.

4. The fluid transport apparatus of claim 1 , wherein the conduit is fluid impervious at −75 degrees Celsius.

5. The fluid transport apparatus of claim 4 , wherein the conduit remains fluid impervious at −100 degrees Celsius.

6. The fluid transport apparatus of claim 1 , wherein the fluid storage accessory comprises a vessel closure.

7. The fluid transport apparatus of claim 1 , wherein the fluid storage accessory comprises a vessel.

8. The fluid transport apparatus of claim 7 , further comprising a sterilizing vent filter engaged with the vessel configured to allow gaseous transfer therethrough.

9. A flexible conduit for directing fluids therethrough, comprising:

a flexible tube formed of platinum catalyzed silicone rubber having methyl and phenyl side groups and having less than 0.5 weight percent extractables, the flexible tube having a storage modulus of 10 8 or less Pascals at −75 degrees Celsius.

10. The flexible conduit of claim 9 , wherein the platinum catalyzed silicone rubber having methyl and phenyl side groups is substantially free of organic solvent.

11. A storage method, comprising:

providing a biological material;

providing a fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough, the fluid transport apparatus comprising:

a conduit having a first terminus and a second terminus, the conduit extending between the first terminus and the second terminus, the conduit formed of platinum catalyzed silicone rubber having methyl and phenyl side groups, the conduit having a storage modulus of 10 8 or less Pascals at −75 degrees Celsius;

at least one fitting connected to the first terminus; and

a vessel engaged with the second terminus;

directing the biological material through the conduit into the vessel;

sealing the vessel at the conduit; and

cryogenically storing the biological material in the vessel.

12. The storage method of claim 11 , wherein providing the biological material comprises providing cells.

13. The storage method of claim 11 , wherein providing the biological material comprises providing therapeutic proteins.

14. The storage method of claim 11 , further comprising engaging a sterilizing vent filter with the vessel to allow gaseous transfer therethrough.

15. The fluid transport apparatus of claim 1 , wherein the conduit is an aseptic conduit.

16. The fluid transport apparatus of claim 1 , wherein the conduit is configured to transfer pharmaceutical products therethrough.

17. The fluid transport apparatus of claim 1 , wherein the conduit is configured to prevent contamination of samples received therein.

18. The fluid transport apparatus of claim 9 , wherein the flexible conduit is an aseptic conduit.

19. The fluid transport apparatus of claim 9 , wherein the flexible conduit is configured to transfer pharmaceutical products therethrough.

20. The fluid transport apparatus of claim 9 , wherein the flexible conduit is configured to prevent contamination of samples received therein.

Assignments (2)
MERGER Recorded Feb 8, 2018
From: ALLPURE TECHNOLOGIES, LLC
To: SARTORIUS STEDIM NORTH AMERICA INC.
Reel/Frame 044871/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2017
From: ZUMBRUM, MICHAEL A
To: ALLPURE TECHNOLOGIES, LLC
Reel/Frame 042028/0876 →
Continuity (1)
Related Publication 20180238475A1 · Aug 23, 2018