Method of making an enhanced flexibility neurovascular catheter
A method of making a high flexibility distal zone on a neurovascular catheter is provided. The method includes the steps of dip coating a removable mandrel to form a tubular inner layer on the mandrel, coating the tubular inner layer with a soft tie layer, applying a helical coil to the outside of the tie layer, positioning a plurality of tubular segments on the helical coil, heating the tubular segments to form the high flexibility distal zone on the neurovascular catheter; and removing the mandrel. The plurality of segments have durometers that decrease in a distal direction. The flexural load profile of the catheter as a function of catheter length is configured to provide enhanced distal flexibility while maintaining high backup support.
1. A method of making a flexible distal zone on a neurovascular catheter, having an elongate tubular body with a distal end, comprising the steps of:
dip coating a removable mandrel to form a tubular inner layer on the mandrel;
coating the tubular inner layer with a tie layer;
applying a helical coil to the outside of the tie layer;
positioning a plurality of tubular segments over the helical coil, the plurality of segments having durometers that decrease in a distal direction, wherein the plurality of tubular segments form a proximal section having a proximal end and a distal end and a durometer equal to or greater than 65D at all points along a length from the proximal end to the distal end of the proximal section, a distal section having a proximal end and a distal end and a durometer equal to or less than 35D at all points along a length extending from the proximal end to the distal end of the distal section, and a transition section extending from the distal end of the proximal section to the proximal end of the distal section, the transition section comprising at least two tubular segments and having a durometer less than 65D and greater than 35D at all points along a length extending from the distal end of the proximal section to the proximal end of the distal section, the transition section being shorter in length than the proximal section and shorter in length than the distal section;
heating the tubular segments to form the flexible distal zone on the neurovascular catheter; and
removing the mandrel.
2. The method as in claim 1 , wherein removing the mandrel step includes axially elongating the mandrel.
3. The method as in claim 1 , comprising positioning at least seven segments on the helical coil.
4. The method as in claim 1 , comprising positioning at least nine segments on the helical coil.
5. The method as in claim 1 , wherein the tubular inner layer comprises PTFE.
6. The method as in claim 1 , wherein the tie layer comprises polyurethane.
7. The method as in claim 6 , wherein the tie layer has a wall thickness of no more than about 0.005 inches.
8. The method as in claim 6 , wherein the tie layer extends along at least the most distal 20 cm of the neurovascular catheter.
9. The method as in claim 1 , wherein the coil comprises a shape memory material.
10. The method as in claim 9 , wherein the coil comprises Nitinol.
11. The method as in claim 10 , wherein the Nitinol comprises an Austenite state at body temperature.
12. The method as in claim 1 , further comprising positioning at least one axially extending tensile strength enhancing filament over the tie layer and extending proximally along the catheter to less than about 40 cm from the distal end.
13. The method as in claim 12 , wherein the filament extends along at least about the most distal 15 cm of the length of the catheter.
14. The method as in claim 12 , wherein the filament extends along at least about the most distal 20 cm of the length of the catheter.
15. The method as in claim 12 , wherein the filament comprises multiple fibers.
16. The method as in claim 1 , wherein the transition section comprises at least three tubular segments.
17. The method as in claim 1 , wherein the distal section is at least about twice as long as the transition section.