Modulators of androgen synthesis
The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.
1. A pharmaceutical composition comprising 0.1 mg to 20 mg of risperidone, 0.1 mg to 20 mg of a 9Z,11E conjugated Linoleic Acid, pharmaceutically-acceptable carriers and/or pharmaceutically-acceptable components, wherein there is a synergistic effect between the therapeutically effective amount of the risperidone and the therapeutically effective amount of a 9Z,11E conjugated Linoleic Acid; and wherein there is an inhibition in tumor growth in a cancer selected from the group consisting of pancreatic, prostate and lung cancer upon the administration of the pharmaceutical composition.
2. The pharmaceutical composition according to claim 1 , wherein the risperidone is in an amount of 0.5 mg to 15 mg.
3. The pharmaceutical composition according to claim 2 , wherein the risperidone is in an amount of 1 mg to 10 mg.
4. The pharmaceutical composition according to claim 3 , wherein the risperidone is in an amount of 1 mg to 5 mg.
5. The pharmaceutical composition according to claim 1 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 0.5 mg to 15 mg.
6. The pharmaceutical composition according to claim 5 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 1 mg to 10 mg.
7. The pharmaceutical composition according to claim 6 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 1 mg to 5 mg.
8. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable carriers include vehicles, stabilizers, diluents, additives, auxiliarys or excipients.
9. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable components include buffers, preservatives, tonicity adjusters, salts, antioxidants, osmolality adjusting agents, physiological substances, pharmacological substances, bulking agents, emulsifying agents, wetting agents, flavoring agents, or coloring agents.
10. A pharmaceutical composition comprising 0.5 mg to 15 mg of risperidone, 0.5 mg to 15 mg of a 9Z,11E conjugated Linoleic Acid, pharmaceutically-acceptable carriers and/or pharmaceutically-acceptable components, wherein there is a synergistic effect between the therapeutically effective amount of the risperidone and the therapeutically effective amount of a 9Z,11E conjugated Linoleic Acid; and wherein there is an inhibition in tumor growth in a cancer selected from the group consisting of pancreatic, prostate and lung cancer upon the administration of the pharmaceutical composition.
11. The pharmaceutical composition according to claim 10 , wherein the risperidone is in an amount of 5 mg to 15 mg.
12. The pharmaceutical composition according to claim 11 , wherein the risperidone is in an amount of 5 mg to 10 mg.
13. The pharmaceutical composition according to claim 10 , wherein the risperidone is in an amount of 1 mg to 10 mg.
14. The pharmaceutical composition according to claim 13 , wherein the risperidone is in an amount of 1 mg to 5 mg.
15. The pharmaceutical composition according to claim 10 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 5 mg to 15 mg.
16. The pharmaceutical composition according to claim 15 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 5 mg to 10 mg.
17. The pharmaceutical composition according to claim 10 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 1 mg to 10 mg.
18. The pharmaceutical composition according to claim 17 , wherein the 9Z,11E conjugated Linoleic Acid is in an amount of 1 mg to 5 mg.
19. The pharmaceutical composition according to claim 10 , wherein the pharmaceutically-acceptable carriers include vehicles, stabilizers, diluents, additives, auxiliarys or excipients, or any combination thereof.
20. The pharmaceutical composition according to claim 10 , wherein the pharmaceutically-acceptable components include buffers, preservatives, tonicity adjusters, salts, antioxidants, osmolality adjusting agents, physiological substances, pharmacological substances, bulking agents, emulsifying agents, thickening agents, wetting agents, flavoring agents, or coloring agents, or any combination thereof.