IP Library › Granted Patent US 10,017,491
Granted Patent B2
US 10,017,491 · App. 15/445,878 · Granted Jul 10, 2018

Compounds and uses thereof for the modulation of hemoglobin

Inventors: Brian W. Metcalf (South San Francisco, CA); Chihyuan Chuang (South San Francisco, CA)
Assignee: Global Blood Therapeutics, Inc.
C07D401/04
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Quick Facts
Patent No.
US 10,017,491
App. No.
15/445,878
Granted
Jul 10, 2018
Kind
B2
Abstract

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Claims (2)

1. A pharmaceutical composition comprising a compound having the structure:

and a pharmaceutically acceptable excipient.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Oct 6, 2022
From: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
To: GLOBAL BLOOD THERAPEUTICS, INC.
Reel/Frame 061620/0186 →
SECOND AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Dec 22, 2021
From: GLOBAL BLOOD THERAPEUTICS, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 058575/0921 →
AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Dec 9, 2020
From: GLOBAL BLOOD THERAPEUTICS, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 054664/0871 →
SECURITY INTEREST Recorded Dec 20, 2019
From: GLOBAL BLOOD THERAPEUTICS, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 051396/0312 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2017
From: METCALF, BRIAN W.
To: GLOBAL BLOOD THERAPEUTICS, INC.
Reel/Frame 043143/0307 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PROPERTY NUMBER OF 14/776,603 PREVIOUSLY RECORDED ON REEL 042183 FRAME 0009. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded May 19, 2017
From: CYTOKINETICS, INC.
To: GLOBAL BLOOD THERAPEUTICS, INC.
Reel/Frame 042503/0238 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PROPERTY NUMBER 14/776,603 NUMBER SHOULD BE 15445878 PREVIOUSLY RECORDED AT REEL: 042182 FRAME: 0887. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded May 19, 2017
From: CHUANG, CHIHYUAN
To: CYTOKINETICS, INC.
Reel/Frame 042503/0085 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 28, 2017
From: CHUANG, CHIHYUAN
To: CYTOKINETICS, INC.
Reel/Frame 042182/0887 →
Continuity (5)
Continuation 14776603
Continuation In Part 13815770 · Mar 15, 2013
Provisional Application 61905802 · Nov 18, 2013
Provisional Application 61905803 · Nov 18, 2013
Related Publication 20170174654A1 · Jun 22, 2017