IP Library › Granted Patent US 10,973,812
Granted Patent B2
US 10,973,812 · App. 15/449,257 · Granted Apr 13, 2021

Ataxia therapeutic compositions and methods

Inventors: Harry T. Orr (Minneapolis, MN); Emily A. L. Wozniak (Minneapolis, MN); Huda Y. Zoghbi (Houston, TX)
Assignees: Regents of the University of Minnesota; Baylor College of Medicine
A61K31/4704A61K9/0024A61K9/10A61K38/07A61K47/02
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Quick Facts
Patent No.
US 10,973,812
App. No.
15/449,257
Granted
Apr 13, 2021
Kind
B2
Abstract

A method for treating a subject having, or at risk of having, ataxia, generally includes administering to the subject an amount of a composition comprising a cholecystokinin receptor (Cck1R) agonist effective to ameliorate at least one symptom or clinical sign of ataxia.

Claims (6)

1. A method for treating a subject having, or at risk of having, ataxia, the method comprising:

administering to the subject having, or at risk of having, ataxia an amount of a composition comprising a cholecystokinin receptor (Cck1R) agonist effective to ameliorate at least one symptom or clinical sign of ataxia.

2. The method of claim 1 wherein the Cck1R agonist is A71623.

3. The method of claim 2 wherein A71623 is administered to the subject to provide a dose of at least 20 μg/kg/day.

4. The method of claim 3 wherein the dose of A71623 is 1 mg/kg/day.

5. The method of claim 1 wherein the Cck1R agonist is rebamipide.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2021
From: ZOGHBI, HUDA
To: BAYLOR COLLEGE OF MEDICINE
Reel/Frame 054969/0179 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 8, 2020
From: ORR, HARRY T.; WOZNIAK, EMILY A.L.
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 052866/0853 →
CONFIRMATORY LICENSE Recorded Apr 18, 2017
From: UNIVERSITY OF MINNESOTA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042271/0927 →
Continuity (2)
Provisional Application 62303122 · Mar 3, 2016
Related Publication 20170252334A1 · Sep 7, 2017