Anti-infective binding proteins that bind AIP2
There is disclosed compositions and methods relating to or derived from anti-AIP2 antibodies. More specifically, there is disclosed fully human antibodies that bind AIP2, AIP2-binding fragments and derivatives of such antibodies, and AIP2-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having AIP2 related disorders or conditions. There is also disclosed a method to treat S. aureus infections by administering an anti-AIP2 antibody described herein.
1. An anti-AIP2 polypeptide that binds to AIP2, wherein the anti-AIP2 polypeptide is a recombinant fully human anti-AIP2 antibody comprising a heavy chain variable domain and a light chain variable domain selected from the group consisting of:
a) a heavy chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 1, and a light chain variable domain the amino acid sequence as set forth in SEQ ID NO. 2;
b) a heavy chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 9, and a light chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 10;
c) a heavy chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 11, and a light chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 12;
d) a heavy chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 13, and a light chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 14;
e) a heavy chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 15, and a light chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 16; and
f) a heavy chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 7, and a light chain variable domain comprising the amino acid sequence as set forth in SEQ ID NO. 8.
2. The anti-AIP2 polypeptide of claim 1 , wherein the anti-AIP2 polypeptide is a Fab fragment.
3. The anti-AIP2 polypeptide of claim 1 , wherein the anti-AIP2 polypeptide is a single chain human antibody.
4. The anti-AIP2 polypeptide of claim 1 wherein the anti-AIP2 polypeptide is selected from the group consisting of a Fab, a Fab′, a F(ab′)2, an Fv, a domain antibody, a single chain antibody, a chimeric antibody, a diabody, a triabody, and a tetrabody.
5. The anti-AIP2 polypeptide of claim 4 , which is a single chain antibody.
6. The anti-AIP2 polypeptide of claim 1 , which has a K D of at least 1×10 −6 M.
7. The anti-AIP2 polypeptide of claim 1 , wherein the the anti-AIP2 polypeptide is classified as an isotype selected from the group consisting of IgG, IgM, IgD, IgA, and IgE.
8. The anti-AIP2 polypeptide of claim 7 , wherein the anti-AIP2 polypeptide is an IgG1 or an IgG4.
9. A pharmaceutical composition comprising the anti-AIP2 polypeptide of claim 1 and a pharmaceutically acceptable carrier.