IP Library › Granted Patent US 10,105,430
Granted Patent B2
US 10,105,430 · App. 15/463,557 · Granted Oct 23, 2018

Method for preventing or treating

Inventor: Martine Marchand (Rixensart, BE)
Assignee: GLAXOSMITHKLINE BIOLOGICALS, S.A.
A61K39/04A61K31/4409A61K31/496C07K14/35A61K2039/523A61K2039/53A61K2039/55566A61K2039/55572A61K2039/55577A61K2039/575
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Quick Facts
Patent No.
US 10,105,430
App. No.
15/463,557
Granted
Oct 23, 2018
Kind
B2
Abstract

The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.

Claims (3)

1. A polypeptide comprising the amino acid sequence of SEQ ID NO: 4.

2. The polypeptide according to claim 1 , consisting of the amino acid sequence of SEQ ID NO: 4.

3. A pharmaceutical composition comprising the polypeptide according to claim 1 , further comprising 3D-MPL and QS21 in a liposome formulation.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2017
From: MARCHAND, MARTINE
To: GLAXOSMITHKLINE BIOLOGICALS, SA
Reel/Frame 043051/0945 →
Continuity (6)
Continuation 14603935 · Jan 23, 2015
Continuation 13895574 · May 16, 2013
Continuation 11912730
Provisional Application 60777017 · Feb 27, 2006
Provisional Application 60676549 · Apr 29, 2005
Related Publication 20170196961A1 · Jul 13, 2017