Granted Patent
B2
US 10,034,881 · App. 15/466,925 · Granted Jul 31, 2018
2,3-disubstituted 1 -acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
Inventors:
Dominique Amans (Middlesex, GB); Stephen John Atkinson (Stevenage, GB); Lee Andrew Harrison (Stevenage, GB); David Jonathan Hirst (Stevenage, GB); Robert Peter Law (Stevenage, GB); Matthew Lindon (Stevenage, GB); Alexander Preston (Stevenage, GB); Jonathan Thomas Seal (Stevenage, GB); Christopher Roland Wellaway (Stevenage, GB)
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Abstract
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
Claims (5)
1. A method of treatment of psoriasis in a human subject in need thereof comprising administering a therapeutically effective amount of a compound which is (2S,3R,4R)-1-acetyl-2-cyclopropyl-3-methyl-4-((4-methylpyrimidin-2-yl)amino)-1,2,3,4-tetrahydroquinoline-6-carboxamide, represented by the formula:
or a pharmaceutically acceptable salt thereof.
2. The method according to claim 1 wherein the compound is in the form of a free base.
3. The method according to claim 1 wherein the compound is administered topically.
4. The method according to claim 2 wherein the compound is administered topically.
Assignments (2)
CHANGE OF ADDRESS
Recorded Apr 16, 2025
From: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
Reel/Frame 070854/0469 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 27, 2017
From: AMANS, DOMINIQUE; ATKINSON, STEPHEN JOHN; HARRISON, LEE ANDREW; HIRST, DAVID JONATHAN; LINDON, MATTHEW J.; PRESTON, ALEXANDER G.; SEAL, JONATHAN THOMAS; LAW, ROBERT PETER; WELLAWAY, CHRISTOPHER ROLAND
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
Reel/Frame 041750/0602 →
Continuity (4)
Division
14770499
Provisional Application
61882798
· Sep 26, 2013
Provisional Application
61781583
· Mar 14, 2013