IP Library Granted Patent US 9,981,975
Granted Patent B2
US 9,981,975 · App. 15/469,975 · Granted May 29, 2018

Pyrrolotriazine compounds as tam inhibitors

Inventors: Yun-Long Li (Chadds Ford, PA); Xiaozhao Wang (Mt. Laurel, NJ); Chunhong He (Chadds Ford, PA)
Assignee: Incyte Corporation
C07D487/04A61K31/53C07D403/04C07D403/14
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,981,975
App. No.
15/469,975
Granted
May 29, 2018
Kind
B2
Abstract

This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Claims (4)

1. A compound, which is N-(4-(4-Amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide, or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

3. A compound, which is N-(4-(4-Amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide.

4. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable carrier.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2017
From: YUN-LONG LI DECEASED BY JENNIFER LI REPRESENTATIVE; WANG, XIAOZHAO; BARBOSA, JOSEPH; BURNS, DAVID M.; FENG, HAO; GLENN, JOSEPH; HE, CHUNHONG; HUANG, TAISHENG; MEI, SONG; ZHUO, JINCONG
To: INCYTE CORPORATION
Reel/Frame 043843/0156 →
Continuity (4)
Provisional Application 62438750 · Dec 23, 2016
Provisional Application 62362934 · Jul 15, 2016
Provisional Application 62314066 · Mar 28, 2016
Related Publication 20170275290A1 · Sep 28, 2017