Arylpiperazine derivatives and methods of utilizing same
The present invention provides arylpiperazine derivatives having Formula I as shown below, which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression,
1. A compound having the formula below or a pharmaceutically acceptable salt or isomer thereof:
wherein a) R 1 =2-OMe and R 2 =H, or b) R 1 =2-Cl and R 2 =3-Cl, and one or more hydrogens of the compound are optionally substituted with 2 H (deuterium).
2. The compound of claim 1 , wherein R 1 =2-Cl and R 2 =3-Cl.
3. The compound of claim 1 , wherein R 1 =2-OMe and R 2 =H.
4. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier, excipient or diluent.
5. A method of treating psychoses, schizophrenia, acute mania, bipolar disorder, autistic disorder or depression, the method comprising administering to a patient in need thereof the pharmaceutical formulation according to claim 4 .
6. The method of claim 5 , wherein said method treats schizophrenia.
7. The method of claim 5 , wherein said method treats bipolar disorder.