IP Library › Patent Application 15472934
Patent Application
App. No. 15/472,934

C-RAF Mutants that Confer Resistance to RAF Inhibitors

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Quick Facts
Patent No.
US None
App. No.
15/472,934
Abstract

Nucleic acids and proteins having a mutant C-RAF sequence, and methods of identifying patients having cancer who are likely to benefit from a combination therapy and methods of treatment are provided.

Claims (1)

1 . An expression vector comprising an isolated nucleic acid molecule encoding a mutant C-RAF polypeptide having C-RAF activity, wherein said mutant C-RAF polypeptide comprises at least one amino acid substitution as compared to a wild type C-RAF polypeptide comprising SEQ. ID. NO. 2, the at least one amino acid substitution conferring resistance to one or more RAF inhibitors on a cell expressing the mutant C-RAF polypeptide.