Compounds as GPR119 agonists

1. A compound of formula (II):

wherein,

Y is selected from H, OH, halogen, C 1-6 alkyl, C 1-6 alkoxy, amino, —NH(Alkyl), —N(Alkyl) 2 , —NH-aralkyl, —CONH 2 , —OCH(CH 3 ) 2 ;

R 1 is selected from:

R 2 is selected from

R 3 is selected from H, OH, halogen, C 1-6 alkyl, C 1-6 alkoxy, amino, —NH(Alkyl), —N(Alkyl) 2 , —NH-aralkyl, —CF 3 , —CH 2 OCH 3 , OR

and pharmaceutically acceptable salts, hydrates and stereoisomers thereof.

2. The compound of claim 1 , having active GLP-1 secretion greater than ˜1 fold with respect to vehicle.

3. The compound of claim 1 , having significant dose dependent glucose reduction at both 3 mpk and 10 mpk in oral glucose tolerance test in rat model.

4. The compound of claim 1 , having significant dose dependent glucose reduction at both 3 mpk and 10 mpk in oral glucose tolerance test in mice model.

5. The compound of claim 1 , showing increase in insulin secretion at an EC50 of less than 1 μM in an in-vitro model of pancreatic beta cells.

6. The compound of claim 1 , wherein R1 is

7. The compound of claim 1 , wherein R1 is

8. The compound of claim 1 , wherein R1 is

9. The compound of claim 1 , wherein Y is hydrogen.

10. A compound of claim 1 having the structure:

1001

3-isopropyl-5-(1-(5-(4-(methyl- sulfonyl)phenoxy)thiazolo [5,4-b]pyridin-2- yl)piperidin-4-yl)-1,2,4- oxadiazole

1002

3-isopropyl-5-(4-(((5-(4- (methylsulfonyl)phenoxy)thiazolo [5,4-b]pyridin-2- yl)oxy)methyl)piperidin-1- yl)-1,2,4-oxadiazole

1003

3-isopropyl-5-(1-(2-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-5- yl)piperidin-4-yl)-1,2,4- oxadiazole

1004

3-isopropyl-5-(1-(5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)piperidin-4-yl)-1,2,4- oxadiazole

1005

3-isopropyl-5-(4-((5-(4- (methylsulfonyl)phenoxy) thiazolo[5,4-b]pyridin-2- yl)oxy)piperidin-1-yl)- 1,2,4-oxadiazole

1006

3-isopropyl-5-(4-(((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)methyl)piperidin-1- yl)-1,2,4-oxadiazole

1007

3-isopropyl-5-(4-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)piperidin-1-yl)- 1,2,4-oxadiazole

1008

2-(4-(5-ethylpyrimidin-2- yl)piperazin-1-yl)-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridine

1009

5-((1-benzylpiperidin-4- yl)methoxy)-2-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridine

1010

2-(4-(5-ethylpyrimidin-2- yl)piperazin-1-yl)-5-(4- (methylsulfonyl)phenoxy) thiazolo[5,4-b]pyridine

1011

isopropyl 4-(5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)-5,6- dihydropyridine-1(2H)- carboxylate

1012

isopropyl 4-(5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl) piperazine-1-carboxylate

1013

isopropyl 4-(5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl) piperidine-1-carboxylate

1014

1-(5-ethylpyrimidin-2-yl)-N- (5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)piperidine- 4-carboxamide

1015

2-(4-(5-(4-(methylsulfonyl) phenyl)thiazolo[5,4- b]pyridin-2-yl)-5,6- dihydropyridin-1(2H)- yl)ethanol

1016

isopropyl 4-(methyl(5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)amino)piperidine-1- carboxylate

1017

N-(1-(5-ethylpyrimidin-2- yl)piperidin-4-yl)-N- methyl-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- amine

1018

isopropyl 4-((5-(4-(dimethyl carbamoyl)phenyl)thiazolo [5,4-b]pyridin-2- yl)(methyl)amino) piperidine-1-carboxylate

1019

isopropyl (5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)carbonate

11. The compound of claim 1 having the structure:

1020

3-isopropyl-5-(4-(1-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1021

3-isopropyl-5-(1-(5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)pyrrolidin-3-yl)-1,2,4- oxadiazole

1022

4-(2-(4-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-1- yl)thiazolo[5,4-b]pyridin- 5-yl)-N,N- dimethylbenzamide

1023

N-(1-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-4- yl)-N-methyl-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- amine

1024

4-(2-(4-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-1- yl)thiazolo[5,4-b]pyridin- 5-yl)-N-(2- methoxyethyl)benzamide

1025

N-(3-fluoro-4- (methylsulfonyl)phenyl)-2- (4-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-1- yl)thiazolo[5,4-b]pyridin- 5-amine

1026

5-(4-(methylsulfonyl)phenyl)- 2-(1-tosyl-1,2,3,6- tetrahydropyridin-4- yl)thiazolo[5,4-b]pyridine

1027

N,N-dimethyl-4-(5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2-yl)- 5,6-dihydropyridine-1(2H)- carboxamide

1028

N,N-dimethyl-4-(5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)piperidine-1- carboxamide

1029

(4-(2-(4-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-1- yl)thiazolo[5,4-b]pyridin- 5-yl)phenyl)(morpholino) methanone

1030

N,N-diisopropyl-4-(5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2-yl)- 5,6-dihydropyridine-1(2H)- carboxamide

1031

(S)-3-isopropyl-5-(4-(1-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1032

(R)-3-isopropyl-5-(4-(1-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1033

3-cyclopropyl-5-(4-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)piperidin-1-yl)- 1,2,4-oxadiazole

1034

isopropyl 4-(2-((5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2- yl)oxy)ethyl)-5,6- dihydropyridine-1(2H)- carboxylate

1035

3-isopropyl-5-(4-(2-((5-(4- (methylsulfonyl)phenyl)thiazolo [5,4-b]pyridin-2- yl)oxy)ethyl)-5,6- dihydropyridin-1(2H)-yl)- 1,2,4-oxadiazole

1036

3-isopropyl-5-(4-(2-methoxy- 1-((5-(4-(methylsulfonyl) phenyl)thiazolo[5,4- b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1037

3-isopropyl-5-(4-(1-((7- methyl-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1038

3-isopropyl-5-(4-(((7-methyl- 5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)methyl)piperidin-1- yl)-1,2,4-oxadiazole

1039

3-isopropyl-5-(4-(1-((6- methyl-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

12. The compound of claim 1 having the structure:

1040

5-(4-(cyclopropyl((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)methyl)piperidin-1- yl)-3-isopropyl-1,2,4- oxadiazole

1041

3-isopropyl-5-(4-(2-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethylidene) piperidin-1-yl)-1,2,4- oxadiazole

1042

3-isopropyl-5-(4-(2-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1043

3-isopropyl-5-(4-(2-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)propyl)piperidin-1- yl)-1,2,4-oxadiazole

1044

3-isopropyl-5-(4-(2-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy) propylidene)piperidin-1- yl)-1,2,4-oxadiazole

1045

(S)-4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5-yl)-N,N- dimethylbenzamide

1046

3-fluoro-4-(2-(1-(1-(3- isopropyl-1,2,4-oxadiazol- 5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5-yl)-N,N- dimethylbenzamide

1047

2-fluoro-4-(2-(1-(1-(3- isopropyl-1,2,4-oxadiazol- 5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5-yl)-N,N- dimethylbenzamide

1048

3-cyclopropyl-5-(4-(1-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1049

N-cyclopropyl-4-(2-(1-(1-(3- isopropyl-1,2,4-oxadiazol- 5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5-yl)benzamide

1050

4-(2-(1-(1-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5-yl)-N-(2- methoxyethyl)benzamide

1051

(4-(2-(1-(1-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5- yl)phenyl)(morpholino) methanone

1052

N-cyclopropyl-4-(2-(1-(1-(3- isopropyl-1,2,4-oxadiazol- 5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4- b]pyridin-5-yl)-N-methyl benzamide

1053

5-(4-(methylsulfonyl)phenyl)- 2-(1-(1-(5- propylpyrimidin-2-yl) piperidine-4- yl)ethoxy)thiazolo[5,4-b] pyridine

1054

3-isopropyl-5-(4-(1-((5- (pyridin-3-yl)thiazolo[5,4- b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-1,2,4- oxadiazole

1055

2-(1-(1-(5-ethylpyrimidin-2- yl)piperidin-4-yl)ethoxy)- 5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridine

1056

isopropyl 4-(1-((5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)oxy)ethyl) piperidine-1-carboxylate

1057

3-isopropyl-5-(4-(1-((5-(4- ((methylsulfonyl)methyl) phenyl)thiazolo[5,4-b] pyridin-2- yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1058

5-isopropyl-3-(4-(1-((5-(4- (methylsulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4- oxadiazole

1059

3-isopropyl-5-(4-(1-((5-(4- (methylsulfonyl)phenyl)thiazolo [5,4-b]pyridin-2- yl)oxy)ethyl)phenyl)-1,2,4- oxadiazole

13. The compound of claim 1 having the structure:

1060

5-(3-fluoro-4-((5-(4-(methyl sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2- yl)oxy)piperidin-1-yl)-3- isopropyl-1,2,4-oxadiazole

1061

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl) ethoxy) thiazolo[5,4-b]pyridin-5- yl)-N-methylbenzene- sulfonamide

1062

5-(4-(1-((5-(4-(ethylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-3-isopropyl- 1,2,4-oxadiazole

1063

5-(4-(1-((5-(4-(cyclopropyl sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-3- isopropyl-1,2,4-oxadiazole

1064

5-(4-(1-((5-(4-(cyclopropyl sulfinyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-3- isopropyl-1,2,4-oxadiazole

1065

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl) ethoxy) thiazolo[5,4-b]pyridin-5- yl)benzonitrile

1066

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridin- 5-yl)-N-(2-methoxyethyl) benzenesulfonamide

1067

3-isopropyl-5-(4-(1-((5-(4- ((2-methoxyethyl)sulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)oxy) ethyl) piperidin-1-yl)-1,2,4- oxadiazole

1068

3-isopropyl-5-(4-(1-((5- (4-((2-methoxyethyl) sulfinyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl) piperidin-1-yl)- 1,2,4-oxadiazole

1069

3-isopropyl-5-(4-(1-((5-(6- (methylsulfonyl)pyridin-3- yl)thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl)piperidin-1- yl)-1,2,4-oxadiazole

1070

(R)-3-isopropyl-5-(4-(1- ((5-(pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-1,2,4- oxadiazole

1071

(R)-4-(2-(1-(1-(3- isopropyl-1,2,4-oxadiazol- 5-yl)piperidin-4- yl)ethoxy)thiazolo[5,4-b] pyridin-5-yl)-1- methylpyridin-1-ium

1072

4-(2-(4-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin-1- yl) thiazolo[5,4-b]pyridin- 5-yl)-N- methylbenzenesulfonamide

1073

4-(2-(4-(3-isopropyl-1,2,4- oxadiazol-5-yl)piperidin- 1-yl)thiazolo[5,4-b] pyridin-5-yl)-N-(2- methoxyethyl)benzene sulfonamide

1074

N-(4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridin-5- yl)phenyl)methane- sulfonamide

1075

2-(1-(1-(1-methyl-1H- tetrazol-5-yl)piperidin-4- yl)ethoxy)-5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridine

1076

(S)-5-(4-(1-((5-(3- fluoropyridin-4- yl)thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl-1,2,4- oxadiazole

1077

3-isopropyl-5-(1-(5- (pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl) piperidin-4-yl)-1,2,4- oxadiazole

1078

3-isopropyl-5-(1-(5-(4-((2- methoxyethyl)sulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)piperidin-4- yl)-1,2,4-oxadiazole

1079

5-(4-(1-((5-(4-(1H- tetrazol-1-yl)phenyl) thiazolo[5,4-b]pyridin-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl-1,2,4- oxadiazole

14. The compound of claim 1 having the structure:

1080

3-isopropyl-5-(1-(5-(6- (methylsulfonyl)pyridin- 3-yl)thiazolo[5,4-b] pyridin-2-yl)piperidin- 4-yl)-1,2,4-oxadiazole

1081

5-(4-(1-((5-(2-fluoro- pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl) oxy)ethyl)piperidin-1- yl)-3-isopropyl-1,2,4- oxadiazole

1082

(S)-3-isopropyl-5-(4-(1- ((5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1083

3-isopropyl-5-(4-(((5- (pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl) oxy)methyl)piperidin- 1-yl)-1,2,4-oxadiazole

1084

5-(4-(((5-(3-fluoro- pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl) oxy)methyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1085

5-(4-(((5-(4-(1H- tetrazol-1-yl)phenyl) thiazolo[5,4-b] pyridin-2-yl)oxy) methyl)piperidin-1- yl)-3-isopropyl-1,2,4- oxadiazole

1086

5-(4-(((5-(2-fluoro- pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl) oxy)methyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1087

2-(1-(1-(5-ethylpyridin- 2-yl)piperidine-4-yl) ethoxy)-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridine

1088

5-(4-(methylsulfonyl) phenyl)-2-(1-(1-(5- vinylpyridin-2-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridine

1089

(S)-5-(4-(methyl- sulfonyl)phenyl)-2- (1-(1-(5-propyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy) thiazolo [5,4-b]pyridine

1090

(R)-5-(4- (methylsulfonyl) phenyl)-2-(1-(1-(5- propylpyrimidin-2- yl)piperidin-4-yl) ethoxy)thiazolo [5,4-b]pyridine

1091

3-isopropyl-5-(4-(((5- (6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridin-2-yl) oxy)methyl)piperidin- 1-yl)-1,2,4-oxadiazole

1092

(S)-3-isopropyl-5-(4- (1-((5-(pyridin-4-yl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4- oxadiazole

1093

(S)-5-(4-(1-((5-(2- fluoropyridin-4- yl)thiazolo[5,4-b] pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1094

3-isopropyl-5-(4- (2,2,2-trifluoro-1- ((5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1095

(S)-5-(4-(1-((5-(4- (cyclopropylsulfonyl) phenyl)thiazolo [5,4-b] pyridin-2-yl) oxy)ethyl)piperidin-1- yl)-3-isopropyl-1,2,4- oxadiazole

1096

(S)-5-(4-(1-((5-(3- fluoropyridin-4- yl)thiazolo[5,4-b] pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1097

2-isopropyl-5-(4-(1- ((5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-1,3,4- oxadiazole

1098

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl) ethoxy) thiazolo[5,4-b]pyridin- 5-yl)pyridine 1-oxide

1099

(S)-5-(6-(methyl- sulfonyl)pyridin-3-yl)- 2-(1-(1-(5-propyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy) thiazolo [5,4-b] pyridine

15. The compound of claim 1 having the structure

1100

5-(4-(1-((5-(3-fluoro-4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1101

(S)-5-(2-fluoropyridin- 4-yl)-2-(1-(1-(5-propyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy) thiazolo [5,4-b] pyridine

1102

3-isopropyl-5-(4- (2,2,2-trifluoro-1-((5- (6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridin-2-yl) oxy) ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1103

3-isopropyl-5-(4- (2,2,2-trifluoro-1- ((5-(2-fluoropyridin- 4-yl)thiazolo[5,4-b] pyridin-2-yl)oxy) ethyl) piperidin-1- yl)-1,2,4-oxadiazole

1104

(S)-2-(1-(1-(5-ethyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(2-fluoropyridin-4- yl)thiazolo[5,4-b] pyridine

1105

3-isopropyl-5-(4-(1- ((5-(4-(methyl sulfonyl)phenyl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) cyclohexyl)-1,2,4- oxadiazole

1106

(S)-2-(1-(1-(5-ethyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl) thiazolo [5,4-b]pyridine

1107

2-(1-(1-(3-isopropyl- 1,2,4-thiadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridine

1108

3-isopropyl-5-(4-(1- ((6-(4-(methyl sulfonyl)phenyl)thiazolo [4,5-b] pyrazin-2-yl) oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1109

2-(1-(1-(cyclopropyl- sulfonyl)piperidin-4- yl)ethoxy)-5-(4- (methylsulfonyl) phenyl)thiazolo[5,4-b] pyridine

1110

6-(4-(methylsulfonyl) phenyl)-2-(1-(1-(5- propylpyrimidin-2-yl) piperidin-4-yl)ethoxy) thiazolo[4,5-b] pyrazine

1111

5-(4-(1-((5-(2-fluoro-4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1112

5-(3-fluoro-4-(1-((5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1113

2-(1-(1-(5-isopropyl- pyrimidin-2-yl)piperidin- 4-yl)ethoxy)-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridine

1114

(S)-3-isopropyl-5-(4-(1- ((6-(6-(methylsulfonyl) pyridin-3-yl) thiazolo [4,5-b]pyrazin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1115

5-(4-(methylsulfonyl) phenyl)-2-(1-(1- (propylsulfonyl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridine

1116

5-(4-(1-((5-(2- chloropyrimidin-5- yl)thiazolo[5,4-b] pyridin-2-yl) oxy) ethyl)piperidin-1-yl)- 3-isopropyl-1,2,4- oxadiazole

1117

1-methylcyclopropyl 4-(1-((5-(4-(methyl- sulfonyl)phenyl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidine-1- carboxylate

1118

5-(4-(methylsulfonyl) phenyl)-2-(1-(1-(5- (prop-1-en-2-yl) pyrimidin-2-yl) piperidin-4-yl)ethoxy) thiazolo [5,4-b] pyridine

1119

(S)-5-(4-(1-((5-(2- chloropyrimidin-5- yl)thiazolo[5,4-b] pyridin-2-yl)oxy) ethyl) piperidin-1-yl)- 3-isopropyl-1,2,4- oxadiazole

16. The compound of claim 1 having the structure:

1120

2-(1-(1-(5-chloro- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridine

1121

3-isopropyl-5-(4-(1-((5- (thiazol-5-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1122

3-isopropyl-5-(4-(1-((5- (isoxazol-4-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1123

3-isopropyl-5-(4-(1-((5- (2-methylpyridin-4-yl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4- oxadiazole

1124

3-isopropyl-5-(4-(1-((5- (isothiazol-4-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1125

3-isopropyl-5-(4-(1-((5- (3-methylisothiazol-4- yl)thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin- 1-yl)-1,2,4-oxadiazole

1126

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridin- 5-yl)pyridin-2(1H)- one

1127

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridin- 5-yl)-1-methylpyridin- 2(1H)-one

1128

5-((3R,4S)-3-fluoro-4- (((5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)oxy)methyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1129

5-((3S,4S)-3-fluoro-4- (((5-(4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)oxy)methyl) piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1130

3-isopropyl-5-(4-(1-(5- (4-(methylsulfonyl) phenyl)thiazolo[5,4-b] pyridin-2-yl)ethoxy) piperidin-1-yl)-1,2,4- oxadiazole

1131

5-(4-(1-((5-(4-(methyl- sulfonyl)phenyl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 3-(trifluoromethyl)- 1,2,4-oxadiazole

1132

5-(4-(1-((5-(2-chloro- pyridin-4-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-3- isopropyl-1,2,4- oxadiazole

1133

3-isopropyl-5-(4-(1- ((5-(2-(methylsulfonyl) pyrimidin-5-yl)thiazolo [5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)- 1,2,4-oxadiazole

1134

3-isopropyl-5-(4-(1- ((5-(pyridazin-4-yl) thiazolo[5,4-b]pyridin- 2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4- oxadiazole

1135

2-((S)-1-(1-(5-ethyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(2-chloropyrimidin- 5-yl)thiazolo[5,4-b] pyridine

1136

2-((S)-1-(1-(5-chloro- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1137

2-(1-(1-(5-cyclopropyl- pyrimidin-2-yl)piperidin- 4-yl)ethoxy)-5-(6- (methylsulfonyl)pyridin- 3-yl)thiazolo[5,4-b] pyridine

1138

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(2-(methylsulfinyl) pyrimidin-5-yl)thiazolo [5,4-b]pyridine

1139

N-(5-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridin-5- yl)pyrimidin-2-yl)-N- methylacetamide

17. The compound of claim 1 having the structure:

1140

2-((R)-1-(1-(3- isopropyl-1,2,4- oxadiazol-5-yl) pyrrolidin-3-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1141

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) pyrrolidin-3-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1142

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-chloropyridin-3- yl)thiazolo[5,4-b] pyridine

1143

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(2-chloropyridin-4- yl)thiazolo[5,4-b] pyridine

1144

1-(5-(2-(1-(1-(3- isopropyl-1,2,4- oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b] pyridin-5-yl)pyridin- 2-yl)imidazolidin- 2-one

1145

2-((S)-1-(1-(3- (trifluoromethyl)-1,2,4- oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1146

1-(5-(2-(1-(1-(3- isopropyl-1,2,4- oxadiazol-5-yl) piperidin-4-yl)ethoxy) thiazolo[5,4-b]pyridin- 5-yl)pyridin-2-yl) pyrrolidin-2-one

1147

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-(trifluoromethyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1148

2-(1-(1-(5-chloro- pyrazin-2-yl)piperidin- 4-yl)ethoxy)-5-(4- (methylsulfonyl)phenyl) thiazolo[5,4-b]pyridine

1149

2-(1-(1-(5-ethyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(pyridin-4-yl) thiazolo[5,4-b]pyridine

1150

2-(1-(1-(5-propyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(pyridin-4-yl)thiazolo [5,4-b]pyridine

1151

2-(1-(1-(5-chloro- pyrazin-2-yl)piperidin- 4-yl)ethoxy)-5-(6- (methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1152

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-(trifluoromethyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1153

2-((S)-1-(1-(5- propylpyrimidin-2- yl)piperidin-4-yl) ethoxy)-5-(pyridin- 4-yl)thiazolo [5,4-b]pyridine

1154

2-((S)-1-(1-(5-ethyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(trifluoromethyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1155

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(3-fluoro-4-(methyl- sulfonyl)phenyl) thiazolo[5,4-b]pyridine

1156

2-(1-(1-(3-ethyl-1,2,4- oxadiazol-5-yl)piperidin- 4-yl)ethoxy)-5-(6- (methylsulfonyl)pyridin- 3-yl)thiazolo[5,4-b] pyridine

1157

2-(1-(1-(5-methyl- pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1158

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(5-(methylsulfonyl) pyrazin-2-yl)thiazolo [5,4-b]pyridine

1159

2-(1-(1-(5-(trifluoro- methyl)pyrimidin-2- yl)piperidin-4-yl) ethoxy)-5-(6- (methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1160

2-((S)-1-(1-(3-ethyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1161

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(5-(methylsulfonyl) pyridin-2-yl)thiazolo [5,4-b]pyridine

1162

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-d]pyrimidine

1163

2-(1-(1-(5-(methoxy- methyl)pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1164

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(6-(cyclopropyl- sulfonyl)pyridin-3-yl) thiazolo[5,4-b]pyridine

1165

2-((R)-1-(1-(5- (methoxymethyl) pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1166

2-((S)-(1-(1-(5- (trifluoromethyl) pyrimidin-2-yl) piperidin-4-yl)ethoxy)- 5-(6-(methylsulfonyl) pyridin-3-yl)thiazolo [5,4-b]pyridine

1167

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(2-fluoro-6-(methyl- sulfonyl)pyridin-3-yl) thiazolo[5,4-b]pyridine

1168

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(2-methyl-6-(methyl- sulfonyl)pyridin-3-yl) thiazolo[5,4-b]pyridine

1169

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl)ethoxy)- 5-(2-methyl-4-(methyl- sulfonyl)phenyl) thiazolo[5,4-b]pyridine

18. The compound of claim 1 , which is

3-isopropyl-5-(1-(5-(4-(methylsulfonyl)phenoxy)thiazolo[5,4-b]pyridin-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(((5-(4-(methylsulfonyl)phenoxy)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(1-(2-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-5-yl)piperidin-4-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(1-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-((5-(4-(methylsulfonyl)phenoxy)thiazolo[5,4-b]pyridin-2-yl)oxy)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)piperidin-1-yl)-1,2,4-oxadiazole;

2-(4-(5-ethylpyrimidin-2-yl)piperazin-1-yl)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

5-((1-benzylpiperidin-4-yl)methoxy)-2-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

2-(4-(5-ethylpyrimidin-2-yl)piperazin-1-yl)-5-(4-(methylsulfonyl)phenoxy)thiazolo[5,4-b]pyridine;

isopropyl 4-(5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)-5,6-dihydropyridine-1 (2H)-carboxylate;

isopropyl4-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl) piperazine-1-carboxylate;

isopropyl-4-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl) piperidine-1-carboxylate;

1-(5-ethylpyrimidin-2-yl)-N-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)piperidine-4-carboxamide;

2-(4-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)-5,6-dihydropyridin-1(2H)-yl)ethanol;

isopropyl-4-(methyl(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)amino)piperidine-1-carboxylate;

N-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-N-methyl-5-(4-(methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2-amine;

isopropyl 4-((5-(4-(dimethyl carbamoyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)(methyl)amino)piperidine-1-carboxylate;

isopropyl (5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl) carbonate;

3-isopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(1-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)pyrrolidin-3-yl)-1,2,4-oxadiazole;

4-(2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)thiazolo[5,4-b]pyridin-5-yl)-N,N-dimethylbenzamide;

N-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)-N-methyl-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-amine;

4-(2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)thiazolo[5,4-b]pyridin-5-yl)-N-(2-methoxyethyl)benzamide; OR

N-(3-fluoro-4-(methylsulfonyl)phenyl)-2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)thiazolo[5,4-b]pyridin-5-amine.

19. The compound of claim 1 , which is

5-(4-(methylsulfonyl)phenyl)-2-(1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)thiazolo[5,4-b]pyridine;

N,N-dimethyl-4-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)-5,6-dihydropyridine-1 (2H)-carboxamide;

N,N-dimethyl-4-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)piperidine-1-carboxamide;

(4-(2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)thiazolo[5,4-b]pyridin-5-yl)phenyl)(morpholino)methanone;

N,N-diisopropyl-4-(5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)-5,6-dihydropyridine-1 (2H)-carboxamide;

(S)-3-isopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(R)-3-isopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-cyclopropyl-5-(4-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)piperidin-1-yl)-1,2,4-oxadiazole;

isopropyl 4-(2-((5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)-5,6-dihydropyridine-1 (2H)-carboxylate;

3-isopropyl-5-(4-(2-((5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)-5,6-dihydropyridin-1 (2H)-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(2-methoxy-1-((5-(4-(methylsulfonyl); phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole 3-isopropyl-5-(4-(1-((7-methyl-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(((7-methyl-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((6-methyl-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

5-(4-(cyclopropyl((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

3-isopropyl-5-(4-(2-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethylidene) piperidin-1-yl)-1,2,4-oxadiazole; OR

3-isopropyl-5-(4-(2-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole.

20. The compound of claim 1 , which is

3-isopropyl-5-(4-(2-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)propyl) piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(2-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)propylidene) piperidin-1-yl)-1,2,4-oxadiazole;

(S)-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-N,N-dimethylbenzamide;

3-fluoro-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-N,N-dimethylbenzamide;

2-fluoro-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-N,N-dimethylbenzamide;

3-cyclopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

N-cyclopropyl-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo [5,4-b]pyridin-5-yl)benzamide;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-N-(2-methoxyethyl)benzamide;

(4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl) ethoxy)thiazolo[5,4-b]pyridin-5-yl)phenyl)(morpholino)methanone;

N-cyclopropyl-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo [5,4-b]pyridin-5-yl)-N-methylbenzamide;

5-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-propylpyrimidin-2-yl) piperidine-4-yl)ethoxy)thiazolo [5,4-b]pyridine;

3-isopropyl-5-(4-(1-((5-(pyridin-3-yl)thiazolo[5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

2-(1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

isopropyl-4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidine-1-carboxylate;

3-isopropyl-5-(4-(1-((5-(4-((methylsulfonyl)methyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

5-isopropyl-3-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)phenyl)-1,2,4-oxadiazole;

5-(3-fluoro-4-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-N-methylbenzenesulfonamide;

5-(4-(1-((5-(4-(ethylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

5-(4-(1-((5-(4-(cyclopropylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

5-(4-(1-((5-(4-(cyclopropylsulfinyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)benzonitrile;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-N-(2-methoxyethyl)benzene sulfonamide;

3-isopropyl-5-(4-(1-((5-(4-((2-methoxyethyl)sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(4-((2-methoxyethyl)sulfinyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(R)-3-isopropyl-5-(4-(1-((5-(pyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(R)-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-1-methylpyridin-1-ium;

4-(2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)thiazolo[5,4-b]pyridin-5-yl)-N-methylbenzenesulfonamide;

4-(2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)thiazolo[5,4-b]pyridin-5-yl)-N-(2-methoxyethyl) benzenesulfonamide;

N-(4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)phenyl)methanesulfonamide;

2-(1-(1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl)ethoxy)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

(S)-5-(4-(1-((5-(3-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

3-isopropyl-5-(1-(5-(pyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(1-(5-(4-((2-methoxyethyl)sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

5-(4-(1-((5-(4-(1H-tetrazol-1-yl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

3-isopropyl-5-(1-(5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridin-2-yl)piperidin-4-yl)-1,2,4-oxadiazole; OR

5-(4-(1-((5-(2-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole.

21. The compound of claim 1 , which is

(S)-3-isopropyl-5-(4-(1-((5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(((5-(pyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole;

5-(4-(((5-(3-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

5-(4-(((5-(4-(1H-tetrazol-1-yl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

5-(4-(((5-(2-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

2-(1-(1-(5-ethylpyridin-2-yl)piperidine-4-yl)ethoxy)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

5-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-vinylpyridin-2-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridine;

(S)-5-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)thiazolo [5,4-b]pyridine;

(R)-5-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)thiazolo [5,4-b]pyridine;

3-isopropyl-5-(4-(((5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole;

(S)-3-isopropyl-5-(4-(1-((5-(pyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(S)-5-(4-(1-((5-(2-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

3-isopropyl-5-(4-(2,2,2-trifluoro-1-((5-(4-(methylsulfonyl)phenyl) thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(S)-5-(4-(1-((5-(4-(cyclopropylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(S)-5-(4-(1-((5-(3-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

2-isopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,3,4-oxadiazole;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl) ethoxy)thiazolo[5,4-b]pyridin-5-yl)pyridine 1-oxide;

(S)-5-(6-(methylsulfonyl)pyridin-3-yl)-2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)thiazolo [5,4-b]pyridine;

5-(4-(1-((5-(3-fluoro-4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(S)-5-(2-fluoropyridin-4-yl)-2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridine;

3-isopropyl-5-(4-(2,2,2-trifluoro-1-((5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridin-2-yl)oxy) ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(2,2,2-trifluoro-1-((5-(2-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4-oxadiazole;

(S)-2-(1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(2-fluoropyridin-4-yl)thiazolo[5,4-b]pyridine;

3-isopropyl-5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl) cyclohexyl)-1,2,4-oxadiazole;

(S)-2-(1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl) thiazolo[5,4-b]pyridine;

2-(1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b]pyridine;

3-isopropyl-5-(4-(1-((6-(4-(methyl sulfonyl)phenyl)thiazolo[4,5-b] pyrazin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

2-(1-(1-(cyclopropylsulfonyl)piperidin-4-yl)ethoxy)-5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b] pyridine;

6-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)thiazolo[4,5-b]pyrazine;

5-(4-(1-((5-(2-fluoro-4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole; OR

5-(3-fluoro-4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole.

22. The compound of claim 1 , which is

2-(1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

(S)-3-isopropyl-5-(4-(1-((6-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[4,5-b]pyrazin-2-yl)oxy) ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

5-(4-(methylsulfonyl)phenyl)-2-(1-(1-(propylsulfonyl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridine;

5-(4-(1-((5-(2-chloropyrimidin-5-yl)thiazolo[5,4-b]pyridin-2-yl) oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

1-methylcyclopropyl4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl) piperidine-1-carboxylate;

5-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-(prop-1-en-2-yl)pyrimidin-2-yl)piperidin-4-yl)ethoxy)thiazolo [5,4-b]pyridine;

(S)-5-(4-(1-((5-(2-chloropyrimidin-5-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

2-(1-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

3-isopropyl-5-(4-(1-((5-(thiazol-5-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(isoxazol-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(2-methylpyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(isothiazol-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(3-methylisothiazol-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)pyridin-2(1H)-one;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one;

5-((3R,4S)-3-fluoro-4-(((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

5-((3S,4S)-3-fluoro-4-(((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)methyl) piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-(5-(4-(methyl sulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)ethoxy)piperidin-1-yl)-1,2,4-oxadiazole;

5-(4-(1-((5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-(trifluoromethyl)-1,2,4-oxadiazole;

5-(4-(1-((5-(2-chloropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(2-(methylsulfonyl)pyrimidin-5-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(pyridazin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((5-(pyridazin-4-yl)thiazolo[5,4-b]pyridin-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

2-((S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(2-chloropyrimidin-5-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-cyclopropylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(2-(methylsulfinyl)pyrimidin-5-yl)thiazolo[5,4-b]pyridine;

N-(5-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)pyrimidin-2-yl)-N-methylacetamide;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine; OR

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-chloropyridin-3-yl)thiazolo[5,4-b]pyridine.

23. The compound of claim 1 , which is

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(2-chloropyridin-4-yl)thiazolo[5,4-b]pyridine;

1-(5-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)pyridin-2-yl)imidazolidin-2-one;

2-((S)-1-(1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

1-(5-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)thiazolo[5,4-b]pyridin-5-yl)pyridin-2-yl)pyrrolidin-2-one;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(trifluoromethyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)ethoxy)-5-(4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(pyridin-4-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(pyridin-4-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(trifluoromethyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(pyridin-4-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(trifluoromethyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(3-fluoro-4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine;

2-(1-(1-(3-ethyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-methylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(5-(methylsulfonyl)pyrazin-2-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(3-ethyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(5-(methylsulfonyl)pyridin-2-yl)thiazolo[5,4-b]pyridine;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-d]pyrimidine;

2-(1-(1-(5-(methoxymethyl)pyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(6-(cyclopropylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((R)-1-(1-(5-(methoxymethyl)pyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)ethoxy)-5-(6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(2-fluoro-6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(2-methyl-6-(methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridine; OR

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-5-(2-methyl-4-(methylsulfonyl)phenyl)thiazolo[5,4-b]pyridine.

24. A method of treating diseases and conditions mediated through GPR119 comprising administering the compound of claim 1 to a patient in need thereof.

25. The method of claim 24 , wherein said disease is metabolic disorder.

26. The method of claim 2 , wherein said disease is diabetes.

27. The method of claim 2 , wherein said disease is Type II diabetes.