Inhibitors of macropinocytosis in prevention and treatment of disease
Described herein are pharmaceutical compositions capable of inhibiting vesicle formation and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat pathogenic infections.
1. A method for treating or preventing an infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein the infection is an Ebolavirus infection or a Marburgvirus infection:
2. A method for treating or preventing an infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition having the general formula (II) or a pharmaceutically acceptable salt thereof, wherein the infection is an Ebolavirus infection or a Marburgvirus infection: