Chiral aziridine phosphoramidate compounds
The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
1. A process for preparing a compound of Formula 4
comprising the steps of:
providing a compound of Formula 3:
wherein R is alkyl or aryl; and
reacting the compound of Formula 3 with a base under conditions effective to produce a compound of Formula 4, wherein the base is potassium hydroxide or potassium carbonate.
2. The process according to claim 1 wherein the R=methyl, ethyl, isopropyl or phenyl.
3. The process according to claim 1 , wherein the step of providing a compound of Formula 3 comprises the steps of:
providing a compound of Formula 2:
wherein R is alkyl or aryl; and
reacting the compound of Formula 2 with methanesulfonyl chloride and a base under conditions effective to produce a compound of Formula 3.
4. The process according to claim 3 wherein the R=methyl, ethyl, isopropyl or phenyl.
5. The process according to claim 3 , wherein said providing a compound of Formula 2 comprises:
providing a compound of Formula 1:
and reacting the compound of Formula II with the appropriate
wherein R=alkyl or aryl,
under conditions effective to produce a compound of Formula 2.
6. The process according to claim 5 wherein the R=methyl, ethyl, isopropyl or phenyl.