Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: where: R independently represents a hydrogen atom, a halogen atom, a (C 1 -C 3 )alkyl group, a —CN group, a hydroxyl group, a —COOR 1 group, a (C 1 -C 3 )fluoroalkyl group, a —NO 2 group, a —NR 1 R 2 group, or a (C 1 -C 3 )alkoxy group; R′ is a hydrogen atom, a halogen atom, a (C 1 -C 3 )alkyl group, a —NO 2 group, a (C 1 -C 3 )alkoxy group, or a —NR 1 R 2 group; and R 1 and R 2 are a hydrogen atom or a (C 1 -C 3 ) alkyl group.
1. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of
2. The compound of claim 1 , wherein the compound is
3. The compound of claim 1 , wherein the compound is
4. The compound of claim 1 , wherein the compound is
5. The compound of claim 1 , wherein the compound is
6. The compound of claim 1 , wherein the compound is
7. The compound of claim 1 , wherein the compound is
8. The compound of claim 1 , wherein the compound is
9. The compound of claim 1 , wherein the compound is
10. A pharmaceutical composition comprising at least one compound of claim 1 and a pharmaceutically acceptable carrier.
11. A method of treating cancer, comprising contacting a cell with at least one compound of claim 1 , wherein the cancer selected from the group consisting of breast cancer, pancreatic cancer, prostate cancer, lung cancer, non-small cell lung cancer, thyroid cancer, liver cancer, and kidney cancer.
12. The method of claim 11 , further comprising a step of administering an effective amount of the at least one compound to a patient in need of cancer treatment.
13. The method of claim 11 , wherein the at least one compound is administered to the patient orally.