Oximetry probe with electronically selectable tissue depth analysis
An oximeter probe includes a probe unit or a base unit and a probe tip where the probe tip has a number of sources and detectors that can be accessed individually or in differing combinations for measuring tissue oxygen saturation at different tissue depth in tissue. A processor of the oximeter probe controls a multiplexer that is coupled to the detectors for selectively collecting measurement information from the detectors via the multiplexer. The oximeter probe is user programmable via one or more input devices on the oximeter probe for selecting the particular sources and detectors to collect measurement information from by the processor.
1. A method comprising:
providing a handheld oximeter housing;
providing a processor housed in the handheld oximeter housing;
providing a memory, housed in the handheld oximeter housing, electronically coupled to the processor;
providing a display, accessible from an exterior of the handheld oximeter housing, electronically coupled to the processor;
providing a battery, housed in the handheld oximeter housing;
providing for the battery to supply power to the processor, the memory, and the display;
providing a probe tip housed at least partially in the handheld oximeter housing;
providing a first source structure on a face of the probe tip;
providing a plurality of detector structures on the face of the probe tip;
providing for the first source structure to emit first light having a first wavelength and second light having a second wavelength into tissue to be measured, wherein the first wavelength is shorter than the second wavelength;
providing for a detection of the first light by the detector structures that are closer to the source structure than a threshold distance;
fitting, by the processor, first detector responses, that are generated by the detector structures that are closer to the source structure than the threshold distance based on the detected first light, to a plurality of simulated reflectance curves stored in the memory;
determining, by the processor, first measurement information for first tissue of the tissue to be measured, based on one or more best fitting ones of the simulated reflectance curve to the first detector responses;
providing for the detection of the second light by the detector structures that are farther from the source structure than the threshold distance; and
fitting, by the processor, second detector responses, that are generated by the detector structures that are farther from the source structure than the threshold distance based on the detected second light, to the plurality of simulated reflectance curves stored in the memory;
determining, by the processor, second measurement information, based on one or more best fitting ones of the simulated reflectance curve to the second detector responses;
determining, via the processor, second measurement information for second tissue of the tissue to be measured based on the second light detected by the detector structures that are farther from the source structure than the threshold distance;
based on the first measurement information, calculating and displaying on the display a first oxygen saturation measurement for a first tissue region below a surface of the tissue at a first depth;
based on the second measurement information, calculating and displaying on the display a second oxygen saturation measurement for a second tissue region below the surface of the tissue at a second depth; and
based on the first measurement information and the second measurement information, calculating and displaying on the display a third oxygen saturation measurement for a third tissue region below the surface of the tissue at a combination of the first and second depths, wherein the first tissue is a first depth below the surface of the tissue to be measured, the second tissue is a second depth below the surface of the tissue to be measured, and the first depth is less than the second depth.
2. The method of claim 1 wherein the first measurement information is first oximetry information and the second information is second oximetry information.
3. The method of claim 1 comprising:
providing a multiplexer, housed in the handheld oximeter housing, coupled to the processor; and
providing the multiplexer to route signals to the processor from the detector structures that are closer to the source structure than the threshold distance.
4. The method of claim 3 comprising providing the multiplexer to not route signals to the processor from the detector structures that are farther from the source structure than the threshold distance.
5. The method of claim 3 wherein the detector structures have an average distance from the first source structure and the threshold distance is the average distance.
6. The method of claim 1 providing for a user selection of a tissue depth of the tissue to be measured for determining the first, second, or third oxygen saturation.
7. The method of claim 1 wherein the determining, by the processor, second measurement information, based on one or more best fitting ones of the simulated reflectance curve to the second detector responses, comprises performing a sum of squares error calculation to determine a specific simulated reflectance curve that has the lowest fit error.
8. The method of claim 1 comprising providing a multiplexer coupled between the processor and the detector structures.
9. The method of claim 1 comprising
providing a probe cover for the handheld oximeter housing comprising:
a first portion of the probe cover, wherein the first portion comprises a first open end and a first closed end, opposite to the first open end, and the first closed end comprises a display panel;
a second portion of the probe cover, wherein the second portion comprises a second open end and a second closed end, opposite to the second open end, the second closed end comprises an optical sensor panel, and coupling of the first open end to the second open end forms a sealed probe cover enclosure for the oximeter device,
the optical sensor panel is transparent and comprises a thickness of less than about 250 microns,
when in the sealed probe cover enclosure, a display of the oximeter device is visible through the display panel of the probe cover, light emitted by a probe tip of the oximeter device is transmitted through the optical sensor panel of the probe cover, and light received at the oximeter device is transmitted through the optical sensor panel of the probe cover,
the sealed probe cover enclosure prevents contaminants from outside of the enclosure from contacting the oximeter device contained within an interior of the enclosure, and
the second portion of the probe cover comprises a barrier at the second closed end, the barrier is coupled to the optical sensor panel, and the barrier prevents contaminants on a tissue being measured from contacting the oximeter contained within the interior of the enclosure.
10. The method of claim 9 wherein the optical sensor panel passes light in a wavelength range from about 650 nanometers to about 900 nanometers without attenuation that would affect an oximeter measurement.
11. The method of claim 9 wherein the optical sensor panel comprises a thickness of less than about 150 microns.
12. The method of claim 9 wherein the optical sensor panel comprises a thickness of less than about 100 microns.
13. The method of claim 9 wherein the optical sensor panel comprises a thickness of less than about 50 microns.
14. The method of claim 9 wherein the thickness of the optical sensor panel comprises a uniform thickness.
15. The method of claim 9 wherein a first surface of the optical sensor panel conforms to a surface of a sensor of the probe tip of the oximeter device, and the first surface is configured to be flush against the sensor of the probe tip without any gaps.
16. The method of claim 9 wherein the probe cover comprises polycarbonate.
17. The method of claim 9 wherein the probe cover comprises a rigid polymer.
18. The method of claim 9 wherein the optical sensor panel comprises polycarbonate.
19. The method of claim 9 wherein the second portion of the probe cover comprises rigid polymer, and the optical sensor panel comprises a flexible polymer, in relation to the rigid polymer.
20. The method of claim 9 wherein the second portion of the probe cover comprises flexible polymer, and the optical sensor panel comprises a rigid polymer, in relation to the flexible polymer.
21. A device comprising:
a handheld oximeter housing;
a processor housed in the handheld oximeter housing;
a memory, housed in the handheld oximeter housing, electronically coupled to the processor and storing a plurality of simulated reflectance curves;
a display, accessible from an exterior of the handheld oximeter housing, electronically coupled to the processor;
a battery, housed in the handheld oximeter housing, wherein the battery is coupled to and supplies power to the processor, the memory, and the display;
a probe tip housed at least partially in the handheld oximeter housing;
a first source structure on a face of the probe tip; and
a plurality of detector structures on the face of the probe tip;
wherein the processor is adapted for:
providing for the detection of a first light by the detector structures that are closer to the first source structure than a threshold distance;
fitting, by the processor, first detector responses, that are generated by the detector structures that are closer to the source structure than the threshold distance based on the detected first light, to the plurality of simulated reflectance curves stored in the memory;
determining, by the processor, first measurement information, based on one or more best fitting ones of the simulated reflectance curve to the first detector responses;
providing for the detection of a second light by the detector structures that are farther from the source structure than the threshold distance;
fitting, by the processor, second detector responses, that are generated by the detector structures that are farther from the source structure than the threshold distance based on the detected second light, to the plurality of simulated reflectance curves stored in the memory;
determining, by the processor, second measurement information, based on one or more best fitting ones of the simulated reflectance curve to the second detector responses;
determining, via the processor, second measurement information for a tissue to be measured based on the second light detected by the detector structures that are farther from the source structure than the threshold distance;
based on the first measurement information, calculating and displaying on the display a first oxygen saturation measurement for a first tissue region below a surface of a tissue at a first depth;
based on the second measurement information, calculating and displaying on the display a second oxygen saturation measurement for a second tissue region below the surface of the tissue at a second depth; and
based on the first measurement information and the second measurement information, calculating and displaying on the display a third oxygen saturation measurement for a third tissue region below the surface of the tissue at a combination of the first and second depths,
wherein the first tissue region is a first depth below a surface of the tissue to be measured, the second tissue region is a second depth below the surface of the tissue to be measured, and the first depth is less than the second depth.
22. The device of claim 21 wherein the first measurement information is first oximetry information and the second information is second oximetry information.
23. The device of claim 21 comprising a multiplexer, housed in the handheld oximeter housing, coupled to the processor, wherein the processor is adapted for providing the multiplexer to route signals to the processor from the detector structures that are closer to the source structure than the threshold distance.
24. The device of claim 23 wherein the processor is adapted for providing the multiplexer to not route signals to the processor from the detector structures that are farther the source structure than the threshold distance.
25. The device of claim 23 wherein the detector structures have an average distance from the first source structure and the threshold distance is the average distance.
26. The device of claim 21 comprising providing for a user selection of a tissue depth of the tissue to be measured for determining the first, second, or third oxygen saturation.
27. The device of claim 26 comprising providing a multiplexer coupled between the processor and the detector structures.