IP Library › Granted Patent US 10,792,347
Granted Patent B2
US 10,792,347 · App. 15/496,106 · Granted Oct 6, 2020

Methods for diagnosing and treating Alzheimer's disease

Inventors: Wilfred Jefferies (Surrey, CA); Kaan E. Biron (North Vancouver, CA); Dara L. Dickstein (New York, NY)
Assignee: Alternative Extracts Inc.
A61K39/0007A61K31/05A61K31/192A61K31/404A61K31/42A61K31/436A61K31/44A61K31/506A61K31/551A61K38/1709A61K38/195A61K38/208A61K38/21A61K38/212A61K38/39A61K38/484C07K16/18C07K16/22G01N33/5058A61K2039/55566A61K2039/575
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Quick Facts
Patent No.
US 10,792,347
App. No.
15/496,106
Granted
Oct 6, 2020
Kind
B2
Abstract

Methods for diagnosing and treating Alzheimer's disease are provided. In particular, methods of restoring blood-brain barrier integrity and/or promoting vascular reversion in a person suffering from Alzheimer's disease by administering an anti-angiogenic agent or an agent that is capable of restoring tight junction integrity. Methods of preventing or delaying the onset of Alzheimer's disease in a subject are also provided.

Claims (5)

1. A method of maintaining and/or restoring tight junction integrity in cerebral vessels and thereby ameliorating symptoms of Alzheimer's Disease in a subject having Alzheimer's Disease consisting of administering to the subject bevacizumab.

2. The method of claim 1 , wherein blood-brain barrier integrity is maintained and/or restored.

3. The method according to claim 1 , wherein there is vascular reversion.

4. A method of maintaining and/or restoring blood-brain barrier (BBB) integrity in a patient having Alzheimer's disease and thereby treating Alzheimer's disease, consisting of administering to the subject bevacizumab.

5. The method according to claim 4 , wherein there is vascular reversion.

Assignments (2)
CHANGE OF NAME Recorded Sep 21, 2020
From: ALTERNATIVE EXTRACTS INC.
To: CAVA HEALTHCARE INC.
Reel/Frame 053830/0117 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2019
From: BIRON, KAAN E.; DICKSTEIN, DARA L.; JEFFERIES, WILFRED A.
To: ALTERNATIVE EXTRACTS INC.
Reel/Frame 049597/0172 →
Continuity (4)
Continuation 14233606
Provisional Application 61687071 · Apr 18, 2012
Provisional Application 61509538 · Jul 19, 2011
Related Publication 20170224792A1 · Aug 10, 2017