IP Library › Granted Patent US 10,780,143
Granted Patent B2
US 10,780,143 · App. 15/501,159 · Granted Sep 22, 2020

Compositions and methods of use for (pro)renin receptor antagonists

Inventors: Yumei Feng Earley (Reno, NV); Tianxin Yang (Salt Lake City, UT)
Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
A61K38/10A61P9/12A61P13/12A61P17/02A61P31/00C07K7/08
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Quick Facts
Patent No.
US 10,780,143
App. No.
15/501,159
Granted
Sep 22, 2020
Kind
B2
Abstract

Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.

Claims (3)

1. A method of treating sepsis comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a (pro)renin receptor (PRR) antagonist, wherein the PRR antagonist is a polypeptide comprising SEQ ID NO:5.

2. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.

3. The method of claim 1 , wherein the polypeptide consists of the amino acid sequence set forth in SEQ ID NO:5.

Assignments (3)
CONFIRMATORY LICENSE Recorded Oct 1, 2020
From: UNIVERSITY OF UTAH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 053966/0302 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 15, 2019
From: UNIVERSITY OF UTAH
To: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Reel/Frame 050063/0207 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 15, 2019
From: FENG EARLEY, YUMEI; YANG, TIANXIN
To: UNIVERSITY OF UTAH
Reel/Frame 050063/0210 →
Continuity (4)
Continuation In Part 14449714 · Aug 1, 2014
Continuation In Part 14032176 · Sep 19, 2013
Provisional Application 61703205 · Sep 19, 2012
Related Publication 20180125922A1 · May 10, 2018