Quinazoline derivative
Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.
1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein
R 1 is —O(CH 2 ) n R 3 ,
wherein
n is 3, 4 or 5, and
R 3 is —NR e R f ,
wherein R e and R f are each independently selected from a group consisting of C 1-6 alkyl, or R e and R f are taken together to form —(CH 2 ) 4 —; and
2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof,
wherein R e and R f are C 1 alkyl.
3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from:
4. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is selected from the group consisting of:
5. A pharmaceutical composition, comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition, comprising the compound of claim 2 or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition, comprising the compound of claim 3 or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition, comprising the compound of claim 4 or a pharmaceutically acceptable salt thereof.
9. A method for preparing the compound of claim 1 or a pharmaceutically acceptable salt thereof, comprising reacting a compound of formula (III) or its salt with a compound of formula (IV) or its salt in a solvent and optionally in the presence of one or more of a catalyst, a base and a surfactant, to obtain the compound of formula (I),
wherein:
R 1 , R 2 , R 3 and n are as defined in claim 1 ,
L represents halogen, hydroxyl, mesyloxy or hydrogen; and
p=0 or 1, with the proviso that when p=1, L is hydrogen.