Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline derivatives, which derivatives have an inhibitory activity against cholesteryl transfer protein (CETP), show effects of increasing HDL cholesterol level and decreasing LDL cholesterol level, and can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, hyperlipidemia, dyslipidemia and the like.
1. A process for preparing the racemic compound of formula I or a salt thereof:
comprising the steps of:
(a) simultaneously reacting 4-aminobenzotrifluoride according to formula II
with an aldehyde according to formula III
and with a compound according to formula IV
in the presence of a solvent and optionally one or more catalysts to form the compound of formula V
wherein
R 1 is H or C 1 -C 3 alkyl;
R 2 is H, C 1 -C 3 alkyl or
(b) hydrolyzing the compound of formula V to form the compound of formula (I); wherein prior to step (b) the compound of formula V is separated from the reaction mixture of step (a).
2. The process according to claim 1 , wherein R 1 is CH 2 CH 3 and R 2 is H.
3. The process according to claim 1 , wherein the solvent used is dichloromethane, acetonitrile, ethyl acetate, toluene or a mixture thereof.
4. The process according to claim 1 , wherein the catalyst used in step a) is an acid, comprising a Brønsted acid or a Lewis acid.
5. The process according to claim 4 , wherein the catalyst is 4-toluenesulfonic acid.
6. The process according to claim 1 , wherein the compound of formula V is separated from the reaction mixture of step (a) by precipitation from the reaction mixture by means of the addition of a non-polar solvent to said reaction mixture.
7. The process according to claim 6 , wherein the non-polar solvent is a heptane, cyclohexane or a mixture thereof.
8. The process according to claim 1 , wherein in step (b) the compound of formula V is hydrolyzed by warming a mixture comprising said compound for 1 hour to 3 hours at a temperature of 45° C. to 80° C. in the presence of an aqueous acid or in the presence of an alcohol and an aqueous acid.
9. The process according to claim 8 , wherein the acid is hydrochloric acid.
10. The process according to claim 8 , wherein the alcohol is ethanol.
11. The process according to claim 1 , further comprising a step c) wherein the 2R,4S-enantiomer of the racemic compound of formula I having a molecular formula according to formula I-a
wherein, R 1 is H or C 1 -C 3 alkyl, is separated from said compound of formula I.
12. The process according to claim 11 , wherein the separation of the enantiomer according to formula I-a is carried out by means of resolution with a chiral resolving agent, such as L-tartaric acid or a derivative thereof, such as di-p-toluoyl-L-tartaric acid.
13. The process according to claim 11 wherein R 1 CH 2 CH 3 .
14. The process according to claim 12 , wherein R 1 is CH 2 CH 3 .
15. The process according to claim 11 , wherein the compound according to formula I-a is obtained with a purity of at least 99% enantiomeric excess (e.e).