IP Library › Granted Patent US 9,988,426
Granted Patent B2
US 9,988,426 · App. 15/509,041 · Granted Jun 5, 2018

Broad spectrum conjugate vaccine to prevent

Inventors: Raphael Simon (Baltimore, MD); Alan Cross (Chevy Chase, MD); Sharon Tennant (Baltimore, MD)
Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
C07K14/26A61K39/0266A61K39/104C07K14/21A61K47/4833A61K2039/70
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Quick Facts
Patent No.
US 9,988,426
App. No.
15/509,041
Granted
Jun 5, 2018
Kind
B2
Abstract

The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

Claims (2)

1. An attenuated Klebsiella pneumoniae serovar strain, comprising an inactivating mutation in the guaBA locus and in the wza-wzc locus.

2. The strain of claim 1 , wherein the serovar is selected from the group consisting of O1, O2a, O3, and O5.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2017
From: SIMON, RAPHAEL; CROSS, ALAN; TENNANT, SHARON
To: UNIVERSITY OF MARYLAND, BALTIMORE
Reel/Frame 043055/0510 →
CONFIRMATORY LICENSE Recorded Jun 26, 2017
From: THE UNIVERSITY OF MARYLAND BALTIMORE
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 042984/0031 →
Continuity (2)
Provisional Application 62052256 · Sep 18, 2014
Related Publication 20170260240A1 · Sep 14, 2017