IP Library › Granted Patent US 10,106,790
Granted Patent B2
US 10,106,790 · App. 15/513,312 · Granted Oct 23, 2018

Intergenic RNAS and methods for modulating gene expression and pathogenesis in

Inventors: Paula R. Sundstrom (Lebanon, NH); Samin Kim (Norwich, VT); Quoc Bao Nguyen (Ho Chi Minh, VN)
Assignee: TRUSTEES OF DARTMOUTH COLLEGE
C12N15/11A61K48/00C07K14/40C12N15/113C12N15/63C12N15/67C12N15/00C12N2310/111C12N2310/113C12N2310/14C12N2310/315C12N2310/341
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Quick Facts
Patent No.
US 10,106,790
App. No.
15/513,312
Granted
Oct 23, 2018
Kind
B2
Abstract

Intergenic non-coding RNA molecules that regulate the expression of HWP1 and ALS3 of Candida are provided as are methods of using the non-coding RNA molecules and complementary molecules thereof in modulating HWP1 or ALS3 expression; adherence, yeast-to-hyphal transition, or biofilm development of Candida ; and preventing or treating candidiasis.

Claims (3)

1. A recombinant vector expressing a nucleic acid molecule consisting of:

(a) SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 or SEQ ID NO:6; or

(b) a nucleotide sequence complementary to a nucleotide sequence of (a).

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 16, 2018
From: DARMOUTH COLLEGE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046548/0590 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2017
From: SUNDSTROM, PAULA R.; KIM, SAMIN; NGUYEN, QUOC BAO
To: TRUSTEES OF DARTMOUTH COLLEGE
Reel/Frame 041703/0914 →
Continuity (2)
Provisional Application 62053372 · Sep 22, 2014
Related Publication 20170298349A1 · Oct 19, 2017