Medicament preparation and treatment devices, methods, and systems

1. A fluid circuit for preparation of a medicament for renal replacement therapy, comprising:

a concentrate container containing acid concentrate connected for flow communication, through a first pumping tube segment, to a medicament supply line that has been capped and sterile-sealed at an outlet end thereof;

a bicarbonate cartridge containing dry bicarbonate buffer compound, the bicarbonate cartridge being of a type that admits water in a cartridge inlet thereby forming a saturated bicarbonate solution which is received at a cartridge outlet, the cartridge outlet being connected for flow communication, through a second pumping tube segment, to the medicament supply line; and

a water inlet line, capped and sterile-sealed, connected for flow communication, through a third pumping tube segment, to the medicament supply line and connected for flow communication to the bicarbonate cartridge inlet;

the first, second, and third pumping tube segments being supported by a circuit cartridge which orients, aligns, and exposes for access the first, second, and third pumping tube segments with respective actuators of a predefined medicament preparation device;

the circuit cartridge containing a first concentration sensor station positioned in said medicament supply line downstream of a first junction where the first pumping tube segment connects to the medicament supply line;

the circuit cartridge containing a second concentration sensor station positioned in said medicament supply line downstream of both said first junction and a second junction where the second pumping tube segment connects to the medicament supply line, wherein

each of said concentration sensor stations includes a liquid conductivity sensor and a temperature sensor portion,

the temperature sensor portion includes a flow chamber with a flat surface to permit a temperature sensor to be placed against said flat surface of a predefined sensor of the predefined medicament preparation device, and

the entire fluid circuit is sterile.

2. The circuit of claim 1 , wherein the circuit cartridge includes a fluid accumulator fluidly coupled between the water inlet line and the medicament supply line outlet end that includes a pressure-regulating urging element that biases a flexible wall of the accumulator such that transient changes of fluid pressure therein cause expansion of the volume of the accumulator.

3. The circuit of claim 1 , wherein the fluid circuit is packaged with a box such that the circuit cartridge can be detached or removed from the box while leaving the concentrate container and bicarbonate cartridge intact therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

4. The circuit of claim 1 , wherein the fluid circuit is packaged within a box such that the circuit cartridge can be removed from the box while leaving the concentrate container and bicarbonate cartridge intact therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

5. The circuit of claim 1 , wherein the fluid circuit is attached to a box in such a way that the circuit cartridge can be detached from the box while leaving the concentrate container and bicarbonate cartridge intact therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

6. The circuit of claim 3 , wherein the box is principally of cardboard.

7. The circuit of claim 1 , wherein each of said concentration stations includes, connected in series, two independent conductivity sensors and two independent temperature sensor portions.

8. The circuit of claim 2 , wherein the medicament supply line includes a waste outlet branch that is in direct fluid communication with the accumulator, the waste outlet branch being capped and sterile-sealed, the medicament supply line outlet line and waste outlet branch having pinching portions supported in an open section of said circuit cartridge to permit access by pinching actuators.

9. A fluid circuit for preparation of a medicament for renal replacement therapy, comprising:

a first container containing acid concentrate connected for flow communication, through a first pumping tube segment, to a medicament supply line that has been capped and sterile-sealed at an outlet end thereof;

a second container containing a buffer concentrate connected for flow communication, through a second pumping tube segment, to the medicament supply line; and

a water inlet line, capped and sterile-sealed, connected for flow communication, through a third pumping tube segment, to the medicament supply line;

the first, second, and third pumping tube segments being supported by a circuit cartridge which orients, aligns, and exposes for access the first, second, and third pumping tube segments with respective actuators of a predefined medicament preparation device;

the circuit cartridge containing a first concentration sensor station positioned in said medicament supply line downstream of a first junction where the first pumping tube segment connects to the medicament supply line;

the circuit cartridge containing a second concentration sensor station positioned in said medicament supply line downstream of both said first junction and a second junction where the second pumping tube segment connects to the medicament supply line, wherein

each of said concentration sensor stations includes a liquid conductivity sensor and a temperature sensor portion,

the temperature sensor portion includes a flow chamber with a flat surface to permit a temperature sensor to be placed against said flat surface of a predefined sensor of the predefined medicament preparation device, and

the entire fluid circuit is sterile.

10. The circuit of claim 9 , wherein the circuit cartridge includes a fluid accumulator fluidly coupled between the water inlet line and the medicament supply line outlet end that includes a pressure-regulating urging element that biases a flexible wall of the accumulator such that transient changes of fluid pressure therein cause expansion of the volume of the accumulator.

11. The circuit of claim 9 , wherein the fluid circuit is packaged with a box such that the circuit cartridge can be detached or removed from the box while leaving the first and second containers therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

12. The circuit of claim 9 , wherein the fluid circuit is packaged within a box such that the circuit cartridge can be removed from the box while leaving the first and second containers therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

13. The circuit of claim 9 , wherein the fluid circuit is attached to a box in such a way that the circuit cartridge can be detached from the box while leaving the first and second containers therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

14. The circuit of claim 11 , wherein the box is principally of cardboard.

15. The circuit of claim 9 , wherein each of said concentration stations includes, connected in series, two independent conductivity sensors and two independent temperature sensor portions.

16. The circuit of claim 10 , wherein the medicament supply line includes a waste outlet branch that is in direct fluid communication with the accumulator, the waste outlet branch being capped and sterile-sealed, the medicament supply line outlet line and waste outlet branch having pinching portions supported in an open section of said circuit cartridge to permit access by pinching actuators.